danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8323-2022-66-6-587-594dan-1098Research ArticleХИМИЯCHEMISTRYКинетика разрушения фибриновых сгустков под действием ультразвуковой кавитацииKinetics of fibrin clots destruction under ultrasonic cavitationАдзерихоИ. Э.AdzerikhoI. E.

Адзерихо Игорь Эдуардович – доктор медицинских наук, профессор.

ул. П. Бровки, 3/3, 220013, Минск

Igor E. Adzerikho – D. Sc. (Medicine), Professor. Belarusian Medical Academy of Postgraduate Education.

3/3, P. Brovka Str., 220013, Minsk

adzerikhoigor@mail.ruКулакА. И.KulakA. I.

Кулак Анатолий Иосифович - академик, доктор химических наук, профессор, директор.

ул. Сурганова, 9/1, 220072, Минск

Anatoly I. Kulak – Academician, D. Sc. (Chemistry), Professor, Director. Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus.

9/1, Surganov Str., 220072, Minsk

kulak@igic.bas-net.byРачокС. М.RachokS. M.

Рачок Светлана Михайловна - кандидат медицинских наук, доцент.

ул. П. Бровки, 3/3, 220013, Минск

Svetlana M. Rachok – Ph. D. (Medicine), Associate Professor. Belarusian Medical Academy of Postgraduate Education.

3/3, P. Brovka Str., 220013, Minsk

svetlana-rachok@yahoo.comМинченяВ. Т.MinchenyaV. T.

Минченя Владимир Тимофеевич - кандидат технических наук, доцент.

ул. Я. Коласа, 24, 220013, Минск

Vladimir T. Minchenya – Ph. D. (Engineering), Associate Professor. Science and Technology Park BNTU “Polytechnic”.

24, Ya. Kolas Str., 220013, Minsk

vlad_minch@mail.ruБелорусская медицинская академия последипломного образованияBelarusian Medical Academy of Postgraduate EducationИнститут общей и неорганической химии Национальной академии наук БеларусиInstitute of General and Inorganic Chemistry of the National Academy of Sciences of BelarusНаучно-технологический парк БНТУ «Политехник»Belarus Scientific and Technological Park of the BNTU “Polytechnic”202203012023666587594Copyright © Адзерихо И.Э., Кулак А.И., Рачок С.М., Минченя В.Т., 20232023Адзерихо И.Э., Кулак А.И., Рачок С.М., Минченя В.Т.Adzerikho I.E., Kulak A.I., Rachok S.M., Minchenya V.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/1098

Изучены кинетические особенности разрушения фибриновых сгустков in vitro под действием ультразвуковой кавитации, генерированной низкочастотным (36 КГц) с интенсивностью I0 4,4–51,2 Вт/см2  ультразвуком (УЗ), с использованием гибкого волновода-концентратора. Установлено, что скорость УЗ разрушения сгустков, погруженных в физиологический раствор, на начальных стадиях процесса пропорциональна I0 в интервале 12–51 Вт/см2, соответствует  кинетике  первого  порядка  и  определяется  протеканием  эрозионных  процессов  без  образования D-димеров и других продуктов фибринолизиса при минимальном вкладе сонохимических реакций. Скорость разрушения сгустка максимальна в начальный момент времени и снижается при увеличении продолжительности УЗ воздействия (на 35 % за 1 мин и на 72 % к концу второй минуты при I0  = 51,2 Вт/см2). Показано, что для увеличения полноты разрушения сгустка при минимально вводимой УЗ дозе целесообразно минимизировать время УЗ воздействия при использовании наиболее высоких значений УЗ интенсивности, ограниченных уровнем безопасного воздействия кавитации на сосудистую стенку, гемостаз и форменные элементы крови.

We studied the kinetic features of fibrin clot destruction in vitro under the action of ultrasonic cavitation generated by low-frequency (36 kHz) ultrasound (US) with the intensity I0  of 4.4–51.2 W/cm2, using a flexible waveguide concentrator. It was established that the rate of US destruction of clots immersed in saline at the initial stage of the process is proportional to I0 in the range of 12–51 W/cm2, corresponds to first-order kinetics, and is determined by the erosive processes without the formation of D-dimers and other fibrinolysis products at a minimum contribution of sonochemical reactions. The clot destruction rate is maximum at the initial time moment and decreases with increasing the US exposure duration (by 35 % in 1 min and by 72 % by the end of the second minute at I0 = 51.2 W/cm2). It was shown that in order to increase the completeness of clot destruction at a minimum administered US dose, it is advisable to minimize the US exposure time when using the highest values of the US intensity limited by the level of safe cavitation exposure to the vascular wall, hemostasis, and blood cells.

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The authors declare that there are no conflicts of interest present.