danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8323-2023-67-4-287-294dan-1139Research ArticleХИМИЯCHEMISTRYЭластификация артериальной стенки под действием высокоинтенсивного низкочастотного ультразвукаElastification of the arterial wall by high-intensity low-frequency ultrasoundАдзерихоИ. Э.AdzerikhoI. E.

Адзерихо Игорь Эдуардович – доктор медицинских наук, профессор

ул. П. Бровки, 3/3, 220013, Минск

Adzerikho Igor E. – D. Sc. (Medicine), Professor

3/3, P. Brovka Str., 220013, Minsk

adzerikhoigor@mail.ruКулакА. И.KulakA. I.

Кулак Анатолий Иосифович − академик, доктор химических наук, профессор, директор

ул. Сурганова, 9/1, 220072, Минск

Kulak Anatoly I. – Academician, D. Sc. (Chemistry), Professor, Director. Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus (

9/1, Surganov Str., 220072, Minsk

kulak@igic.basnet.byВладимирскаяТ. Э.VladimirskayaT. E.

Владимирская Татьяна Эрнстовна – кандидат биологических наук

ул. П. Бровки, 3/3, 220013, Минск

Vladimirskaya Tatyana E. – Ph. D. (Biology)

3/3, P. Brovka Str., 220013, Minsk

tan_2304@inbox.ruЛеончикЕ. В.LeonchikT. V.

Леончик Екатерина Владимировна – младший научный сотрудник

ул. П. Бровки, 3/3, 220013, Минск

Leonchik Ekaterina V. – Junior Researcher

3/3, P. Brovka Str., 220013, Minsk

Katherine.leonchik@gmail.comЧурС. Н.ChurS. N.

Чур Сергей Николаевич – кандидат медицинских наук, доцент

пр. Дзержинского, 83, 220083, Минск

Chur Sergey N. – Ph. D. (Medicine), Associate Professor

83, Dzerzhinsky Ave., 220083, Minsk

serchur@rambler.ruМинченяВ. Т.MinchenyaV. T.

Минченя Владимир Тимофеевич − кандидат технических наук, доцент

ул. Я. Коласа, 24, 220013, Минск

Minchenya Vladimir T. – Ph. D. (Engineering), Associate Professor

24, Y. Kolas Str., 220013, Minsk

vlad_minch@mail.ruШилькоС. В.Shil’koS. V.

Шилько Сергей Викторович − кандидат технических наук, доцент

ул. Кирова, 32а, 246050, Гомель

Shil’ko Sergei V. – Ph. D. (Engineering), Associate Professor

32a, Kirov Str., 246050, Gomel

shilko_mpri@mail.ruБелорусская медицинская академия последипломного образованияBelarusian Medical Academy of Postgraduate EducationИнститут общей и неорганической химии Национальной академии наук БеларусиInstitute of General and Inorganic Chemistry of the National Academy of Sciences of BelarusБелорусский государственный медицинский университетBelarusian State Medical UniversityНаучно-технологический парк Белорусского национального технического университета «Политехник»Scientific and Technological Park of the Belarusian National Technical University “Polytechnic”Институт механики металлополимерных систем имени В. А. Белого Национальной академии наук БеларусиV. A. Bely Metal-Polymer Research Institute of the National Academy of Sciences of Belarus202301092023674287294Copyright © Адзерихо И.Э., Кулак А.И., Владимирская Т.Э., Леончик Е.В., Чур С.Н., Минченя В.Т., Шилько С.В., 20232023Адзерихо И.Э., Кулак А.И., Владимирская Т.Э., Леончик Е.В., Чур С.Н., Минченя В.Т., Шилько С.В.Adzerikho I.E., Kulak A.I., Vladimirskaya T.E., Leonchik T.V., Chur S.N., Minchenya V.T., Shil’ko S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/1139

Установлено существенное повышение эластичности бедренно-подколенных сегментов артерий in vitro в результате действия кавитации, генерированной мощным низкочастотным (24–26 кГц) ультразвуком, вводимым внутрь кровеносного сосуда гибким волноводом. Эластичность сосуда оценивалась как по прогибу под действием внешней силы, так и по степени его вазодилатации внутренним давлением, создаваемым расширяющимся баллоном. Показана возможность достижения более чем двукратного снижения модуля упругости сосудистой стенки после 30 с ультразвукового воздействия интенсивностью 31 Вт/см2. Установлено, что при амплитуде ультразвуковых колебаний 10 мкм имеет место повреждение сосудистой стенки в виде мелких фокусов отслоения и разрыва интимы, сопровождающееся расслоениями в медии с формированием полиморфных щелевидных полостей при увеличении амплитуды колебаний свыше 23 мкм.

A significant increase in the elasticity of the femoropopliteal artery segments in vitro was found as a result of the action of cavitation generated by powerful low-frequency (24–26 kHz) ultrasound introduced into the vessel by a flexible waveguide. The vessel elasticity was evaluated both by the deflection under the action of an external force and by the degree of its expansion vasodilatation by the internal pressure created by the expanding balloon. The possibility of achieving a more than two-fold decrease in the vascular wall elasticity modulus after 30-s exposure to an ultrasound intensity of 31 W/cm2 was shown. It has been established that at the 10 μm amplitude of ultrasonic vibrations, vascular wall damage occurs in the form of small foci of detachment and rupture of the intima accompanied by delamination in the media layer, when polymorphic slit-like cavities are formed with an increase in the amplitude of oscillations above 23 μm.

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The authors declare that there are no conflicts of interest present.