danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8323-2023-67-4-295-299dan-1140Research ArticleХИМИЯCHEMISTRYПротивокоронавирусные свойства брассиностероидовAnti-coronavirus properties of brassinosteroidsЖабинскийВ. Н.ZhabinskiiV. N.

Жабинский Владимир Николаевич – член-корреспондент, доктор химических наук, доцент, главный научный сотрудник

ул. Купревича, 5/2, 220084, Минск

Zhabinskii Vladimir N. – Corresponding Member, D. Sc. (Chemistry), Assistant Professor, Chief Researcher

5/2, Kuprevich Str., 220084, Minsk

vz@iboch.byМаторинА. М.MatorinA. M.

Маторин Алексей Михайлович – младший научный сотрудник

ул. Купревича, 5/2, 220084, Минск

Matorin Alexey M. – Junior Researcher

5/2, Kuprevich Str., 220084, Minsk

matorin@iboch.byСавиноваО. В.SavinovaO. V.

Савинова Ольга Владимировна – старший научный сотрудник

ул. Филимонова, 23, 220114, Минск

Savinova Olga V. – Senior Researcher

23, Filimonov Str., 220114, Minsk

briem@tut.byБорекоЕ. И.BorekoE. I.

Бореко Евгений Иванович – доктор медицинских наук, доцент, главный научный сотрудник

ул. Филимонова, 23, 220114, Минск

Boreko Evgeny I. – D. Sc. (Medicine), Assistant Professor, Chief Researcher

23, Filimonov Str., 220114, Minsk

e.i.boreko@gmail.comХрипачВ. А.KhripachV. A.

Хрипач Владимир Александрович – академик, доктор химических наук, профессор, заведующий лабораторией

ул. Купревича, 5/2, 220084, Минск

Khripach Vladimir A. – Academician, D. Sc. (Chemistry), Professor, Head of the Laboratory

5/2, Kuprevich Str., 220084, Minsk

khripach@iboch.byИнститут биоорганической химии Национальной академии наук БеларусиInstitute of Bioorganic Chemistry of the National Academy of Sciences of BelarusРеспубликанский научно-практический центр эпидемиологии и микробиологииRepublican Research and Practical Center for Epidemiology and MicrobiologyРеспубликанский научно-практический центр эпидемиологии и микробиологии2Republican Research and Practical Center for Epidemiology and Microbiology202301092023674295299Copyright © Жабинский В.Н., Маторин А.М., Савинова О.В., Бореко Е.И., Хрипач В.А., 20232023Жабинский В.Н., Маторин А.М., Савинова О.В., Бореко Е.И., Хрипач В.А.Zhabinskii V.N., Matorin A.M., Savinova O.V., Boreko E.I., Khripach V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/1140

На примере сезонного респираторного альфа-коронавируса человека 229Е (HCoV-229E) проведено изучение противовирусных свойств природных брассиностероидов кампестанового, эргостанового и стигмастанового рядов (6-кетонов и B-лактонов) и их соответствующих (22S,23S)-аналогов. Показано наличие противокоронавирусных свойств для ряда изученных соединений. 6-Кетоны в целом оказались более активными в сравнении с B-лактонами. Максимальный показатель ингибирующего действия (EC50 21,1 µM) в отношении репродукции HCoV-229E отмечен для (22S,23S)-эпикастастерона.

Antiviral properties of natural brassinosteroids of the campestane, ergostane, and stigmastane series (6-ketones and B-lactones) and their (22S,23S)-analogs were studied using the seasonal human respiratory alpha-coronavirus 229E (HCoV-229E) as an example. The presence of anticoronavirus properties was shown for a number of studied compounds. In general, 6-ketones were more active than B-lactones. The maximum inhibitory effect (EC50 21.1 µM) in relation to the reproduction of HCoV-229E was noted for (22S,23S)-epicastasterone.

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The authors declare that there are no conflicts of interest present.