danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8323-2024-68-5-365-372dan-1211Research ArticleФИЗИКАPHYSICSКвантовая запутанность в паре ионов цинка РНК-зависимой РНК-полимеразы флавивирусов и ее роль в реакции полимеризацииQuantum entangle in a zinc ion pair of RNA-dependent RNA polymerase of flaviviruses and its role in the polymerization reactionПотаповаУ. В.PotapovaU. V.

Потапова Ульяна Валерьевна – ассистент.

ул. Свердлова, 13а, 220006, Минск

Ulyana V. Potapova – Assistant, Belarusian State Technological University.

13a, Sverdlov Str., 220006, Minsk

shuana1983@yandex.ruФеранчукС. И.FeranchukS. I.

Феранчук Сергей Ильич – канд. физ.-мат. наук.

Sergey I. Feranchuk – Ph. D. (Physics and Mathematics).

feranchuk@gmail.comБатяновскийА. В.BatyanovskiiA. V.

Батяновский Александр Валерьевич – канд. физ.-мат. наук, ст. науч. сотрудник.

ул. Сурганова, 6, 220012, Минск

Alexander V. Batyanovskii – Ph. D. (Physics and Mathematics), Senior Researcher, United Institute of Informatics Problems of the National Academy of Sciences of Belarus.

6, Surganov Str., 220012, Minsk

alexandersn@newman.bas-net.byМатусковД. С.MatuskovD. S.

Матусков Дмитрий Сергеевич – студент.

ул. Свердлова, 13а, 220006, Минск

Dmitry S. Matuskov – Student, Belarusian State Technological University.

13a, Sverdlov Str., 220006, Minsk

dimamatuscob@gmail.comФеранчукИ. Д.FeranchukI. D.

Феранчук Илья Давыдович – д-р физ.-мат. наук, профессор.

пр. Независимости 4, 220030, Минск

Ilya D.Feranchuk – D. Sc. (Physics and Mathematics), Professor. Belarusian State University.

4, Nezavisimosti Ave., 220030, Minsk

iferanchuk@gmail.comБелорусский государственный технологический университетBelarusian State Technological UniversityОбъединенный институт проблем информатики Национальной академии наук БеларусиUnited Institute of Informatics Problems of the National Academy of Sciences of BelarusБелорусский государственный университетBelarusian State University202406112024685365372Copyright © Потапова У.В., Феранчук С.И., Батяновский А.В., Матусков Д.С., Феранчук И.Д., 20242024Потапова У.В., Феранчук С.И., Батяновский А.В., Матусков Д.С., Феранчук И.Д.Potapova U.V., Feranchuk S.I., Batyanovskii A.V., Matuskov D.S., Feranchuk I.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/1211

Белок полимеразы флавивирусов в процессе реакции полимеризации претерпевает структурные изменения. Белок содержит два атома цинка, каждый из которых координируется четырьмя аминокислотами белка. Рассмотрена возможность квантового перехода в атомах цинка. Показано, что в силу квантовой запутанности этот переход происходит совместно в обоих атомах. С помощью моделирования молекулярной динамики показано, что малые возмущения структуры, связанные с совместным переходом атомов цинка, приводят к изменениям третичной структуры полимеразы. Обсуждается возможность обозначенного явления в других цинксодержащих белках.

The flavivirus polymerase protein undergoes structural changes during the polymerization reaction. The protein contains two zinc atoms, each of which is coordinated by four amino acids of the protein. The possibility of a quantum transition in zinc atoms is considered. It is shown that due to quantum entanglement this transition occurs jointly in both atoms. Using molecular dynamics modeling, it is shown that small perturbations of the structure associated with the joint transition of zinc atoms lead to structural changes in the polymerase. The prevalence of this phenomenon on other zinc-containing proteins is discussed.

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The authors declare that there are no conflicts of interest present.