<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">dan</journal-id><journal-title-group><journal-title xml:lang="ru">Доклады Национальной академии наук Беларуси</journal-title><trans-title-group xml:lang="en"><trans-title>Doklady of the National Academy of Sciences of Belarus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-8323</issn><issn pub-type="epub">2524-2431</issn><publisher><publisher-name>The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">dan-145</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICINE</subject></subj-group></article-categories><title-group><article-title>АНАЛИЗ ЭФФЕКТИВНОСТИ ИСПОЛЬЗОВАНИЯ ПРОСТАТСПЕЦИФИЧЕСКОГО АНТИГЕНА ДЛЯ ОЦЕНКИ РИСКА РАЗВИТИЯ РАКА ПРОСТАТЫ ПРИ ПРОВЕДЕНИИ СЛУЧАЙ-КОНТРОЛЬ ИССЛЕДОВАНИЙ</article-title><trans-title-group xml:lang="en"><trans-title>ANALYSIS OF THE EFFICIENCY OF PROSTATE-SPECIFIC ANTIGEN USE FOR PROSTATE CANCER RISK EVALUATION UNDER CASE-CONTROL INVESTIGATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ПАВЛОВА</surname><given-names>Н. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>PAULAVA</surname><given-names>N. F.</given-names></name></name-alternatives><email xlink:type="simple">pavlova@fizio.bas-net.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ТОЛПЕКО</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>TOLPEKO</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">esikat@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>МАНЬКОВСКАЯ</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>MANKOVSKAYA</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">mankovskaya@fizio.bas-net.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ЗАЛУЦКИЙ</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>ZALUTSKI</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>член-корреспондент</p></bio><email xlink:type="simple">biblio@fizio.bas-net.by</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт физиологии НАН Беларуси, Минск</institution></aff><aff xml:lang="en"><institution>Institute of Physiology of the National Academy of Sciences of Belarus, Minsk</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Минский городской клинический онкологический диспансер, Минск</institution></aff><aff xml:lang="en"><institution>Minsk City Clinical Oncologic Dispensary, Minsk</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>06</day><month>06</month><year>2016</year></pub-date><volume>59</volume><issue>5</issue><fpage>68</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ПАВЛОВА Н.Ф., ТОЛПЕКО А.А., МАНЬКОВСКАЯ С.В., ЗАЛУЦКИЙ И.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">ПАВЛОВА Н.Ф., ТОЛПЕКО А.А., МАНЬКОВСКАЯ С.В., ЗАЛУЦКИЙ И.В.</copyright-holder><copyright-holder xml:lang="en">PAULAVA N.F., TOLPEKO A.A., MANKOVSKAYA S.V., ZALUTSKI I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://doklady.belnauka.by/jour/article/view/145">https://doklady.belnauka.by/jour/article/view/145</self-uri><abstract><p>В результате проведенного анкетирования и на основании результатов лабораторных исследований 674 сотрудников НАН Беларуси выделена группа риска, куда вошли мужчины, уровень ПСА общий в сыворотке крови которых превышал значение 4,0 нг/мл, а соотношение ПСА свободный/ПСА общий было меньше 15 %. Установлена несомненная причинная связь недостаточной физической нагрузки в жизни сотрудников НАН Беларуси, употребление алкоголя, курение, наследственная предрасположенность и возможное развития рака простаты.</p></abstract><trans-abstract xml:lang="en"><p>674 men of the National Academy of Sciences of Belarus were recruited in effort to be inspected both for evaluation of prostate-specific antigen (PSA) in serum blood and for filling a questionnaire. The group of a prostate cancer risk was selected among examined persons, who had a PSA level &gt;4.0 ng/ml, and the PSA free/PSA total level was &lt;15 %. We found a significant causation between lower physical activity, alcohol consumption, cigarette smoking, and prostate cancer risk.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак простаты</kwd><kwd>простатспецифический антиген</kwd><kwd>факторы риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>prostate cancer</kwd><kwd>prostate specific antigen</kwd><kwd>rick factors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lifestyle behaviors, obesity, and perceived health among men with and without a diagnosis of prostate cancer: A population-based, cross-sectional study / L. G. Rogers [et al.] // BMC Public health. – 2008. – Vol. 22. – P. 8–23.</mixed-citation><mixed-citation xml:lang="en">Lifestyle behaviors, obesity, and perceived health among men with and without a diagnosis of prostate cancer: A population-based, cross-sectional study / L. G. Rogers [et al.] // BMC Public health. – 2008. – Vol. 22. – P. 8–23.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гиновкер, А. Г. Рак предстательной железы / А. Г. Гиновкер // Вестн. СурГУ. Медицина. – 2011. – № 9. – С. 76–87.</mixed-citation><mixed-citation xml:lang="en">Гиновкер, А. Г. Рак предстательной железы / А. Г. Гиновкер // Вестн. СурГУ. Медицина. – 2011. – № 9. – С. 76–87.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Прогноз числа ежегодных случаев злокачественных новообразований в Республике Беларусь и областях до 2030 года: статистический сборник / И. В. Залуцкий [и др.] // Статистический сборник. – Минск, 2011. – 40 c.</mixed-citation><mixed-citation xml:lang="en">Прогноз числа ежегодных случаев злокачественных новообразований в Республике Беларусь и областях до 2030 года: статистический сборник / И. В. Залуцкий [и др.] // Статистический сборник. – Минск, 2011. – 40 c.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Первый опыт скрининга рака предстательной железы в Республике Беларусь / С. А. Красный [и др.] // Сибирский онколог. журн. – 2013. – № 3. – С. 66–69.</mixed-citation><mixed-citation xml:lang="en">Первый опыт скрининга рака предстательной железы в Республике Беларусь / С. А. Красный [и др.] // Сибирский онколог. журн. – 2013. – № 3. – С. 66–69.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Insulin-Like Growth Factor (IGF) family and prostate cancer / C. Gennigens [et al.] // Critical Reviews in Oncology/ Hematology. – 2006. – Vol. 58. – Р. 124–145.</mixed-citation><mixed-citation xml:lang="en">Insulin-Like Growth Factor (IGF) family and prostate cancer / C. Gennigens [et al.] // Critical Reviews in Oncology/ Hematology. – 2006. – Vol. 58. – Р. 124–145.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Рак предстательной железы: некоторые аспекты эпидемиологии, этиологии и канцерогенеза / С. Х. Аль-Щукри [и др.] // Урологические ведомости. – 2012. – № 1, т. 1. – С. 23–25.</mixed-citation><mixed-citation xml:lang="en">Рак предстательной железы: некоторые аспекты эпидемиологии, этиологии и канцерогенеза / С. Х. Аль-Щукри [и др.] // Урологические ведомости. – 2012. – № 1, т. 1. – С. 23–25.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Имянитов, Е. Н. Эпидемиология и биология рака простаты / Е. Н. Имянитов // Практическая онкология. – 2008. – Т. 9, № 2. – С. 68–74.</mixed-citation><mixed-citation xml:lang="en">Имянитов, Е. Н. Эпидемиология и биология рака простаты / Е. Н. Имянитов // Практическая онкология. – 2008. – Т. 9, № 2. – С. 68–74.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a populationbased nonscreened cohort / Par Stattin [et al.] // J. of clinical oncology. – 2004. – N 15. – P. 3104–3112.</mixed-citation><mixed-citation xml:lang="en">High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a populationbased nonscreened cohort / Par Stattin [et al.] // J. of clinical oncology. – 2004. – N 15. – P. 3104–3112.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Рак предстательной железы и наследственные синдромы / Н. Ф. Белев [и др.] // Злокачественные опухоли. – 2014. – № 3. – С. 97–102.</mixed-citation><mixed-citation xml:lang="en">Рак предстательной железы и наследственные синдромы / Н. Ф. Белев [и др.] // Злокачественные опухоли. – 2014. – № 3. – С. 97–102.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Energy balance, physical activity, and cancer risk / A. M. Fair [et al.] // Methods Mol Biol. – 2009. – Vol. 472. – P. 57–88.</mixed-citation><mixed-citation xml:lang="en">Energy balance, physical activity, and cancer risk / A. M. Fair [et al.] // Methods Mol Biol. – 2009. – Vol. 472. – P. 57–88.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Impact of Diet, Body Mass Index, and Physical Activity on Cancer Survivalv / E. Kampman [et al.] // Curr. Nutr. Rep. – 2012. – Vol. 7. – P. 30–36.</mixed-citation><mixed-citation xml:lang="en">Impact of Diet, Body Mass Index, and Physical Activity on Cancer Survivalv / E. Kampman [et al.] // Curr. Nutr. Rep. – 2012. – Vol. 7. – P. 30–36.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Smoking as a risk factor for prostate cancer: a meta-analysis of 24 prospective cohort studies / M. Huncharek [et al.] // Am. J. Public Health. – 2010. – Vol. 100, N 4. – P. 693–701.</mixed-citation><mixed-citation xml:lang="en">Smoking as a risk factor for prostate cancer: a meta-analysis of 24 prospective cohort studies / M. Huncharek [et al.] // Am. J. Public Health. – 2010. – Vol. 100, N 4. – P. 693–701.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">The diet as a cause of human prostate cancer / W. G. Nelson [et al.] // Cancer Treat. Res. – 2014. – Vol. 159. – P. 51–68.</mixed-citation><mixed-citation xml:lang="en">The diet as a cause of human prostate cancer / W. G. Nelson [et al.] // Cancer Treat. Res. – 2014. – Vol. 159. – P. 51–68.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
