danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"dan-146Research ArticleМЕДИЦИНАMEDICINEМЕТИЛИРОВАНИЕ ГЕНА RUNX3 КАК ФАКТОР ПРОГНОЗА ПРИ РАКЕ МОЧЕВОГО ПУЗЫРЯ БЕЗ МЫШЕЧНОЙ ИНВАЗИИRUNX3 GENE METHYLATION AS A PROGNOSTIC FACTOR IN NON-MUSCLE-INVASIVE BLADDER CANCERСМАЛЬМ. П.SMALM. P.M.Smal@igc.byРОЛЕВИЧА. И.ROLEVICHA. I.alexander.rolevich@gmail.comНАБЕБИНАТ. И.NABEBINAT. I.nabebina.t@yandex.byКРАСНЫЙС. А.KRASNYS. A.

член-корреспондент

SergeyKrasny@tut.byГОНЧАРОВАР. И.GONCHAROVAR. I.R.Goncharova@igc.byИнститут генетики и цитологии НАН Беларуси, МинскInstitute of Genetics and Cytology of the National Academy of Sciences of Belarus, MinskРНПЦ онкологии и медицинской радиологии им. Н. Н. Александрова, ЛеснойN. N. Alexandrov National Cancer Center of Belarus, Lesnoy2015070620165957378Copyright © СМАЛЬ М.П., РОЛЕВИЧ А.И., НАБЕБИНА Т.И., КРАСНЫЙ С.А., ГОНЧАРОВА Р.И., 20162016СМАЛЬ М.П., РОЛЕВИЧ А.И., НАБЕБИНА Т.И., КРАСНЫЙ С.А., ГОНЧАРОВА Р.И.SMAL M.P., ROLEVICH A.I., NABEBINA T.I., KRASNY S.A., GONCHAROVA R.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/146

Проведен анализ статуса метилирования гена RUNX3 в проспективной группе из 262 пациентов, страдающих раком мочевого пузыря (РМП). В отличие от нормального уротелия, в опухолевых клетках мочевого пузыря наблюдалась высокая частота гиперметилирования промоторной области гена RUNX3, равная 63 %. Выявлена статистически значимая ассоциация эпигенетических нарушений исследуемого гена с агрессивным опухолевым фенотипом: высокой степенью распространения, низкой степенью дифференцировки и большими размерами опухоли. Установлено, что гиперметилирование гена RUNX3 являлось независимым фактором риска в отношении прогрессирования и онкоспецифической выживаемости в группе пациентов с РМП без мышечной инвазии.

The analysis of the RUNX3 gene methylation status was conducted in the prospective group of 262 bladder cancer patients. In comparison to normal urothelium, a high frequency (63 %) of RUNX3 promoter hypermethylation was observed in tumor tissues. А statistically significant association of RUNX3 epigenetic abnormalities with a more aggressive tumor phenotype – an advanced tumor stage and grade, as well as a large tumor size – was found. We have shown that RUNX3 hypermethylation is an independent risk factor for progression and cancer-specific survival in the group of patients with non-muscle invasive bladder cancer.

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The authors declare that there are no conflicts of interest present.