danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"dan-17Research ArticleМЕДИЦИНАMEDICINEГЕНЕТИЧЕСКИЙ ПОЛИМОРФИЗМ АРОМАТАЗЫ У ПАЦИЕНТОК С СЕРОЗНЫМ РАКОМ ЯИЧНИКОВ В РЕСПУБЛИКЕ БЕЛАРУСЬGENE POLYMORPHISM OF AROMATASE IN PATIENTS WITH SEROUS OVARIAN CANCER IN THE REPUBLIC OF BELARUSМИХАЛЕНКОЕ. П.MIKHALENKAА. P.E.Michalenko@igc.bas-net.byШЕЛКОВИЧС. Е.SHELKOVICHS. E.s.shelkovich@mail.ruЧЕБОТАРЕВАН. В.CHEBOTAREVAN. V.n.chebotareva@mail.ruЩАЮКА. Н.SCHAYUKA. N.anyuta_8a@mail.ruМАЙСЕНЯЕ. Н.MAISENIAE. N.an-el@mail.ruДЕМИДЧИКЮ. Е.DEMIDCHIKYu. E.

член-корреспондент

yu.demidchik@gmail.comКРУПНОВАЭ. В.KRUPNOVAE. V.ekrupnova@inbox.ruИнститут генетики и цитологии НАН Беларуси, МинскInstitute of Genetics and Cytology of the National Academy of Sciences of Belarus, MinskБелорусская медицинская академия последипломного образования, МинскBelarusian Medical Academy of Post-Graduate Education, MinskМинский городской клинический онкологический диспансер, МинскMinsk City Clinical Oncologic Dispensary, Minsk, Belarus2016210520166018286Copyright © МИХАЛЕНКО Е.П., ШЕЛКОВИЧ С.Е., ЧЕБОТАРЕВА Н.В., ЩАЮК А.Н., МАЙСЕНЯ Е.Н., ДЕМИДЧИК Ю.Е., КРУПНОВА Э.В., 20162016МИХАЛЕНКО Е.П., ШЕЛКОВИЧ С.Е., ЧЕБОТАРЕВА Н.В., ЩАЮК А.Н., МАЙСЕНЯ Е.Н., ДЕМИДЧИК Ю.Е., КРУПНОВА Э.В.MIKHALENKA А.P., SHELKOVICH S.E., CHEBOTAREVA N.V., SCHAYUK A.N., MAISENIA E.N., DEMIDCHIK Y.E., KRUPNOVA E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/17

В работе изучена частота распределения полиморфных вариантов гена ароматазы у белорусских пациенток с серозным раком яичников. В данной популяции пациентов установлена связь генетического полиморфизма rs10046 с риском развития серозного рака яичников у женщин старше 50 лет: генотип СТ в группе пациенток встречался достоверно реже (OR = 0,58; 95 % CI: 0,37–0,91; р = 0,023).

The aim of the present research was to study the frequency of the distribution of variants of gene polymorphism of aromatase (СYP19A1) in Belarusian patients with serous ovarian cancer. This population established the influence of gene polymorphism rs10046 with the risk of serous ovarian cancer in women older than 50 years: CT genotype in a group of patients with serous ovarian cancer was met significantly less than in the control group (OR = 0.58; 95 % CI: 0.37–0.91; p = 0.023).

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The authors declare that there are no conflicts of interest present.