danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"dan-340Research ArticleМЕДИЦИНАMEDICINEПРОГНОСТИЧЕСКИЕ ФАКТОРЫ ПРИ ЛЕЧЕНИИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫPROGNOSTIC FACTORS IN THE TREATMENT OF BREAST CANCERШУКАНОВАН. А.SHUKANOVAN. A.natashu2006@yandex.ruДУБОВСКАЯЛ. В.DUBOVSKAYAL. V.dubovsk@mail.ruБАКАКИНАЮ. С.BAKAKINAY. S.bakakinay@mail.ruМАРТЫНОВАМ. А.MARTYNOVAM. A.martynova@ibp.org.byКОЗЛОВСКАЯН. А.KAZLOUSKAYAN. A.oncomammolog@tut.byШАПОВАЛЕ. В.SHAPOVALE. V.jaklin60@rambler.ruБУШМАКИНАИ. М.BUSHMAKINAI. M.МОЛЧАНМ. М.MOLCHANM. M.Институт биофизики и клеточной инженерии НАН БеларусиInstitute of Biophysics and Cell Engineering of the National Academy of Sciences of BelarusРНПЦ онкологии и медицинской радиологии им. Н. Н. АлександроваN. N. Alexandrov National Cancer Centre of Belarus201630102016604104108Copyright © ШУКАНОВА Н.А., ДУБОВСКАЯ Л.В., БАКАКИНА Ю.С., МАРТЫНОВА М.А., КОЗЛОВСКАЯ Н.А., ШАПОВАЛ Е.В., БУШМАКИНА И.М., МОЛЧАН М.М., 20162016ШУКАНОВА Н.А., ДУБОВСКАЯ Л.В., БАКАКИНА Ю.С., МАРТЫНОВА М.А., КОЗЛОВСКАЯ Н.А., ШАПОВАЛ Е.В., БУШМАКИНА И.М., МОЛЧАН М.М.SHUKANOVA N.A., DUBOVSKAYA L.V., BAKAKINA Y.S., MARTYNOVA M.A., KAZLOUSKAYA N.A., SHAPOVAL E.V., BUSHMAKINA I.M., MOLCHAN M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/340

Установлено, что активность бутирилхолинэстеразы в цельной крови пациенток с доброкачественными опухолями молочной железы ниже по сравнению с этим показателем при злокачественных образованиях (Р < 0,001). На гель-электрофореграммах плазмы крови пациенток с раком молочной железы обнаружено изменение белковой экспрессии и появление новых белковых онкомаркеров, которые зависят от молекулярно-генетического подтипа опухоли. Выявленные различия позволят разработать дополнительные методы диагностики и прогнозирования результатов терапии.

It was shown that the butyrylcholinesterase activity in the blood of women with non-malignant breast cancer was lower as compared to patients with malignant breast cancer (P < 0,001). Using two dimensional gel-electrophoresis method it was found that blood plasma proteomic maps are different for patients with various molecular subtypes of breast cancer. Identified differences consist in the appearance of additional new proteins and changes in the expression of proteins present in norm. Current data provide an advance to develop supplemental methods of breast cancer diagnosis and prognosis of the therapy outcomes.

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The authors declare that there are no conflicts of interest present.