danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"dan-443Research ArticleХИМИЯCHEMISTRYСИНТЕЗ ФУНКЦИОНАЛЬНО ЗАМЕЩЕННЫХ ПРОИЗВОДНЫХ ПИРИМИДИНА НА ОСНОВЕ (E)-3-(4,5-ДИХЛОРИЗОТИАЗОЛ-3-ИЛ)-1-ФЕРРОЦЕНИЛПРОП-2-ЕН-1-ОНАSYNTHESIS OF FUNCTIONALLY SUBSTITUTED PYRIMIDINE DERIVATIVES BASED ON (E)-3- (4,5-DICHLOROISOTHIAZOL-3-YL)-1-FERROCENYLPROP-2-EN-1-ONEПоткинВ. И.PotkinV. I.

член-корреспондент, д-р хим. наук, профессор, заведующий отделом

Corresponding Member, D. Sc. (Chemistry), Professor, Head of the Department

potkin@ifoch.bas-net.byКлецковА. В.KletskovA. V.

науч. сотрудник

Researcher

avkletskov@gmail.comПеткевичС. К.PetkevichS. K.

канд. хим. наук, ст. науч. сотрудник

Ph. D. (Chemistry), Senior researcher

petkevich@ifoch.bas-net.byКолесникИ. А.KolesnikI. A.

мл. науч. сотрудник

Junior researcher

irynakolesnik93@gmail.comЗубковФ. И.ZubkovF. I.

канд. хим. наук, доцент

Ph. D. (Chemistry), Assistant Professor

fzubkov@sci.pfu.edu.ruКвятковскаяЕ. А.KvyatkovskayaE. A.liza_kv3094@mail.ruБорисоваК. К.BorisovaK. K.

лаборант

Assistant

borisova_ks67@mail.ruПоповА. В.PopovA. V.

канд. хим. наук, науч. сотрудник

Ph. D. (Chemistry), Researcher 

popov@irioch.irk.ruРозенцвейгИ. Б.RozentsveigI. B.

д-р хим. наук, доцент, заместитель директора

D. Sc. (Chemistry), Assistant Professor, Deputy Director

i_roz@irioch.irk.ruИнститут физико-органической химии Национальной академии наук БеларусиInstitute of Physical Organic Chemistry of the National Academy of Sciences of BelarusРоссийский университет дружбы народовPeoples’ Friendship University of RussiaИркутский институт химии им. А. Е. Фаворского Сибирского отделения Российской академии наукA. E. Favorskii Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences2017051020176147782Copyright © Поткин В.И., Клецков А.В., Петкевич С.К., Колесник И.А., Зубков Ф.И., Квятковская Е.А., Борисова К.К., Попов А.В., Розенцвейг И.Б., 20172017Поткин В.И., Клецков А.В., Петкевич С.К., Колесник И.А., Зубков Ф.И., Квятковская Е.А., Борисова К.К., Попов А.В., Розенцвейг И.Б.Potkin V.I., Kletskov A.V., Petkevich S.K., Kolesnik I.A., Zubkov F.I., Kvyatkovskaya E.A., Borisova K.K., Popov A.V., Rozentsveig I.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/443

Конденсацией ацетилферроцена с 4,5-дихлоризотиазол-3-карбальдегидом синтезирован 3-(4,5-ди-хлоризотиазол-3-ил)-1-ферроценилпроп-2-ен-1-он. Реакция полученного изотиазолилферроценилкетона с гуанидином приводила к аминозамещенному ферроценилизотиазолилпиримидину. Взаимодействие изотиазолилферроценилкетона с тиомочевиной протекало путем гетероциклизации с образованием ферроценилизотиазолил-3,4-ди-гидропиримидин-2(1H)-тиона. Полученные гибридные азагетероциклические производные ферроцена представляют интерес для биотестирования в качестве противоопухолевых агентов.

 

 

 

 

3-(4,5-Dichloroisothiazol-3-yl)-1-ferrocenylprop-2-en-1-one was synthesized by condensation of acetyl ferro-cene with 4,5-dichloroisothiazole-3-carbaldehyde. The reaction of isothiazolylferrocenyl ketone obtained with guanidine resulted in amino substituted ferrocenylisothiazolyl pyrimidine. The interaction of isothiazolylferrocenyl ketone with thiourea proceeded by heterocyclization, leading to the formation of ferrocenylisothiazolyl-3,4-dihydropyrimidin-2(1H)-thione. Hybrid derivatives of azaheterocycles and ferrocene are of interest for biotesting as antitumor agents.

 

 

 

 

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The authors declare that there are no conflicts of interest present.