danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8323-2018-62-1-73-77dan-491Research ArticleБИОЛОГИЯBIOLOGYСТРУКТУРНЫЕ ДЕТЕРМИНАНТЫ ВЫТЕСНЕНИЯ БЕЛКА Bax ИЗ КОМПЛЕКСА TOM/Bax БЕЛКОМ tBid ПРИ АПОПТОЗЕSTRUCTURAL DETERMINANTS OF Bax DISPLACMENT FROM THE TOM/Bax COMPLEX BY tBid DURING APOPTOSISУрбанВ. А.UrbanViktor A.

мл. науч. сотрудник

ул. Академическая, 27, 220072, Минск

Junior researcher

27, Akademicheskaya Str., 220072, Minsk

urban@ibp.org.byДудкоА. В.DudkoHanna V.

мл. науч. сотрудник

ул. Академическая, 27, 220072, Минск

Junior researcher

27, Akademicheskaya Str., 220072, Minsk

dudko@ibp.org.byВересовВ. Г.VeresovValery G.

д-р биол. наук, гл. науч. сотрудник

ул. Академическая, 27, 220072, Минск

D. Sc. (Biology), Chief researcher

27, Akademicheskaya Str., 220072, Minsk

veresov@ibp.org.byИнститут биофизики и клеточной инженерии Национальной академии наук БеларусиInstitute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus2018040320186217377Copyright © Урбан В.А., Дудко А.В., Вересов В.Г., 20182018Урбан В.А., Дудко А.В., Вересов В.Г.Urban V.A., Dudko H.V., Veresov V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/491

Активация белка Bax, его встраивание в наружную мембрану митохондрий и последующая олигомеризация приводят к пермеабилизации наружной мембраны митохондрий и апоптозу. Механизмы активации белка Bax при апоптозе до настоящего времени остаются неясными. Недавно было установлено, что активация Bax иногда опосредуется его связыванием и взаимодействием c белком TOM22 комплекса TOM на наружной мембране митохондрий, однако понимание этого явления на структурном уровне до настоящего времени отсутствует. В настоящей работе установлены структурные факторы, вызывающие про-апоптотическую активацию белка Bax белком TOM22 комплекса TOM и BH3-only – белком tBid. 

Structural factors that induce the proapoptotic activation of Bax by the protein TOM22 of the TOM complex and BH3-only protein tBid are established. 

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The authors declare that there are no conflicts of interest present.