danДоклады Национальной академии наук БеларусиDoklady of the National Academy of Sciences of Belarus1561-83232524-2431The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8323-2020-64-4-457-465dan-903Research ArticleМЕДИЦИНАMEDICINEВлияние методов экстракорпоральной детоксикации на уровни заменимых аминокислот в плазме крови у пациентов с сепсисом (Представлено членом-корреспондентом Н.С. Сердюченко)Influence of the extracorporeal detoxication methods on the levels of nonessential amino acids in the blood plasma of patients with sepsis (Communicated by Corresponding Member Nikolay S. Serduchenko)https://orcid.org/0000-0002-8699-8216ЯкубцевичР. Э.YakubtsevichR. E.

Якубцевич Руслан Эдуардович - доктор медицинских наук, доцент, заведующий кафедрой, ГрГМУ.

ул. Горького, 80, 230009, Гродно.

Yakubtsevich Ruslan E. - D. Sc. (Medicine), Associate professor, Head of the Department, Grodno State Medical University.

80, Gorky Str., 230009, Grodno.

jackruslan@tut.byhttps://orcid.org/0000-0003-0452-8876БелявскийН. В.BelyavskyN. V.

Белявский Николай Викторович - врач анестезиолог-реаниматолог, ГОКБ.

Бульвар Ленинского комсомола, 52, 230030, Гродно.

Belyavsky Nickolay V. - Anesthesiologist-rheanimatologist, Grodno Regional Clinical Hospital.

52, Leninsky Komsomol Boulevard, 230030, Grodno.

neurogames@gmail.comГлазевА. А.GlazevA. A.

Глазев Антон Анатольевич - кандидат биологических наук, заместитель проректора, ГрГУ им. Янки Купалы.

ул. Ожешко, 22, 230023, Гродно.

Glazev Anton A. - Ph. D. (Biology), Deputy Vice-Rector, Yanka Kupala Grodno State University.

22, Ozheshko Str., 230023, Grodno.

anton.glazev@rambler.ruКлисаС. Д.KlisaS. D.

Клиса Сергей Дмитриевич - младший научный сотрудник, ГрГУ им. Янки Купалы.

ул. Ожешко, 22, 230023, Гродно.

Klisa Sergey D. - Junior researcher, Yanka Kupala Grodno State University.

22, Ozheshko Str., 230023, Grodno.

siarogyk@mail.ruГродненский государственный медицинский университетGrodno State Medical UniversityГродненская областная клиническая больницаGrodno Regional Clinical HospitalГродненский государственный университет имени Я. КупалыYanka Kupala Grodno State University202030082020644457465Copyright © Якубцевич Р.Э., Белявский Н.В., Глазев А.А., Клиса С.Д., 20202020Якубцевич Р.Э., Белявский Н.В., Глазев А.А., Клиса С.Д.Yakubtsevich R.E., Belyavsky N.V., Glazev A.A., Klisa S.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.belnauka.by/jour/article/view/903

Недостатком методов экстракорпорального очищения крови (ЭОК) описывается возможное снижение концентрации в плазме крови ряда важных метаболитов. Нарушения обмена аминокислот при сепсисе проявляются расстройствами микроциркуляции, снижением иммунного ответа и увеличением смертности. Цель исследования - изучить влияние ЭОК на динамику уровней заменимых аминокислот в плазме крови у пациентов с сепсисом. Материалы и методы: отобраны 28 пациентов с диагнозом «сепсис», к которым применялись методы гемосорбции с различными сорбентами, плазмафильтрации, гемофильтрации. Результаты. У пациентов после гемосорбции сорбентом «Протеазосорб» установлено достоверное снижение уровней аспарагина, фосфоэтаноламина, пролина; α-аминомасляная кислота продемонстрировала достоверное повышение. У пациентов после гемофильтрации установлено достоверное снижение уровней в плазме орнитина, аспарагиновой кислоты, 3-метилгистидина, 1-метилгистидина. Выводы. Методы ЭОК оказывают значимое влияние на концентрации в плазме некоторых аминокислот.

Some disadvantages of the extracorporeal blood purification (EBP) methods as reducing plasma levels of different important metabolites are described. Disorders of amino acid metabolism in sepsis are manifested into microcirculation interruptions, a decreased immune response and an increased mortality. The aim of the study is to investigate the EBP influence on the levels of nonessential amino acids in the blood plasma of patients with sepsis. 28 patients diagnosed with “sepsis” were selected. Standard treatment protocols of plasma filtration, hemofiltration and hemadsorption with various sorbents were used. A significant decrease in the levels of asparagine, phosphoethanolamine, proline; α-aminobutyric acid showed a significant increase in these levels in patients who underwent “Proteasosorb” sorbent hemadsorption. A significant decrease in the levels of ornithine, aspartic acid, 3-methylhistidine, 1-methylhistidine in patients treated with hemofiltration was found. The EBP methods significantly influence the amino acid metabolism.

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The authors declare that there are no conflicts of interest present.