Importance of thyroid status in forming characteristics of body temperature changes in rats and rabbits depending on the severity of bacterial endotoxinemia
https://doi.org/10.29235/1561-8323-2025-69-2-144-149
Abstract
Using physiological, biochemical and pharmacological methods in experiments on rats and rabbits, it was shown that the direction and nature of body temperature changes, taking into account the action of bacterial lipopolysaccharide – endotoxin E. coli, depend on the severity of endotoxinemia, the state of the liver detoxification function. It was revealed that when bacterial endotoxin is introduced into the body in trace concentrations, body temperature and the activity of detoxification processes increase, and in the case of severe endotoxinemia, they decrease. It has been established that the ambiguous direction and nature of changes in body temperature in the conditions of endotoxinemia development depend on its severity, the state of the liver’s detoxification function and the thyroid status of the body.
About the Author
F. I. Vismont
Belarusian State Medical University
Belarus
Belarus
Vismont Frantishek I. – Corresponding Member, D. Sc.
(Medicine), Professor, Head of the Department
83, Dzerzhinsky Ave, 220116,
Minsk
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