SEMICONDUCTOR NANOPARTICLES OF CADMIUM SELENIDE AS FLUORESCENT CELL MARKER
Abstract
Cytotoxicity and the cellular uptake of different-coated fluorescent semiconductor nanoparticles CdSe/ZnS were studied. The cellular uptake of fluorescent semiconductor nanoparticles in vitro depends on the nanoparticle construction (coating composition and to a lesser extent on the core size), the type of cells, and the stage of cell differentiation. Cytotoxicity of fluorescent semiconductor nanoparticles is determined by the coating composition. Non-specific labeling of cells was demonstrated in vitro using fluorescent semiconductor nanoparticles coated with cysteine, and mercaptoundecanoic and thioglycolic acids. Fibronectin-modified fluorescent semiconductor nanoparticles with carboximethyldextran-shell bind by target tumor cells in vitro. Nanoparticles coated with cysteine are suitable for cell visualization in lymph nodes after intraperitoneal injection.
About the Authors
Е. А. PETROVA
Institute of Physiology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
T. I. TERPINSKAYA
Institute of Physiology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
M. V. ARTEMYEV
Institute for Physico-Chemical Problems of Belarusian State University
Belarus
Belarus
V. S. ULASHCHYK
Institute of Physiology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
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