BASIC CHARACTERISTICS OF SPECIFIC TRIIDOTHYRONINE BINDING WITH CELL-TARGETS OF PATIENTS WITH THYROID CARSINOMA DURING TREATMENT
Abstract
The parameters of specific triidothyronine binding with lymphocytes of patients operated for highly differentiated thyroid cancer and received comprehensive treatment, on the average, for 15 years are studied. These patients have revealed a significant increase of interaction affinity and a decrease in the number of binding places in comparison with these characteristics of the persons of the control group. A relationship of the studied indices between the factors of treatment and its duration is shown. Patients with overweight have revealed a significant increase in interaction affinity and a decrease in the number of binding places as compared to patients with normal weight, which explains a decreased need in triiodothyronine in this group of patients.
About the Authors
T. A. MITYUKOVA
Institute of Physiology of National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Т. А. LEONOVA
Minsk City Clinical Oncologic Dispensary, Minsk
Belarus
Belarus
S. V. MANKOVSKAYA
Institute of Physiology of National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
О. V. SVIRIDOV
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
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