INFLUENCE OF HUMAN RECOMBINANT LACTOFERRIN ON THE LEVEL OF SEX HORMONES IN MALE RATS OF DIFFERENT AGE
Abstract
A systemic administration of human recombinant lactoferrin to male rats caused an increase in a total testosterone level by 200 % in blood serum, the estradiol concentration decreased significantly by 16.7 %. Upon completion of administration, testosterone was still increased (p < 0.05) for 7 weeks, gradually returning to the control group values without inhibition of endogenous testosterone synthesis. In contrast, the level of estradiol returned to control values. Our study of the rat model of age-related hypogonadism revealed that a systemic per os administration of human recombinant lactoferrin to experimental animals had a significant stimulatory effect on testosterone biosynthesis in 2-yearolds, restoring it to the level of physiological values in young rats.
About the Authors
Ju. A. Rudnichenko
Institute of Physiology of the National Academy of Sciences of Belarus, Minsk
Belarus
Junior researcher
Belarus
Junior researcher
U. S. Lukashevich
Institute of Physiology of the National Academy of Sciences of Belarus, Minsk
Belarus
Senior researcher
Belarus
Senior researcher
I. V. Zalutsky
Institute of Physiology of the National Academy of Sciences of Belarus, Minsk
Belarus
Corresponding Member, D. Sc. (Medicine), Professor, Director
Belarus
Corresponding Member, D. Sc. (Medicine), Professor, Director
References
1. Konaka H., Sugimoto K., Orikasa H., Iwamoto T., Takamura T., Takeda Y., Shigehara K., Iijima M., Koh E., Namiki M. Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter randomized controlled trial in Japan (EARTH Study). Asian Journal of Andrology, 2016, vol. 18, no. 1, pp. 25–34. doi.org/10.4103/1008-682x.148720.
2. Coss C. C., Jones A., Hancock M. L., Steiner M. S., Dalton J. T. Selective androgen receptor modulators for the treatment of late onset male hypogonadism. Asian Journal of Andrology, 2014, vol. 16, no. 2, pp. 256–261. doi.org/10.4103/1008- 682x.122339.
3. Lukashevich V. S., Budevich A. I ., Semak I. V., Kuznetsova V. N., Malyushkova E. V., Pyzh A. E., Novakovskaya S. A., Rudnichenko Yu. A., Popkov N. A., Ivashkevich O. A., Zalutsky I. V. Production of recombinant human lactoferrin from the milk of goat-producers and its physiological effects. Doklady Natsional’noi akademii nauk Belarusi [Doklady of the National Academy of Sciences of Belarus], 2016, vol. 60, no. 1, pp. 72–81 (in Russian).
4. Giansanti F., Panella G., Leboffe L., Antonini G. Lactoferrin from Milk: Nutraceutical and Pharmacological Properties. Pharmaceuticals, 2016, vol. 9, no. 4, pp. 61. doi.org/10.3390/ph9040061.
5. Rudnichenko Ju. Impact of human lactoferrin on the testosterone level in the hypothalamic-pituitary-gonadal axis rats. Vestsі Natsyianal’nai akademіі navuk Belarusі. Seryia medytsynskіkh navuk [Proceedings of the National Academy of Sciences of Belarus, medical series], 2015, no. 2, pp. 102–104 (in Russian).
6. Andreollo N. A., dos Santos E. F., Araújo M. R., Lopes L. R. Rat’s age versus human’s age: what is the relationship? Arquivos Brasileiros de Cirurgia Digestiva, 2012, vol. 25, no. 1, pp. 49–51. doi.org/10.1590/s0102-67202012000100011.
7. Chen H., Ge R. S., Zirkin B. R. Leydig cells: From stem cells to aging. Molecular and Cellular Endocrinology, 2009, vol. 306, no. 1–2, pp. 9–16. doi.org/10.1016/j.mce.2009.01.023.
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