Regulation of high-frequency rhythms of the behavioral activity by oligopeptides structurаlly related to oxytocin
https://doi.org/10.29235/1561-8323-2021-65-2-191-198
Abstract
The pharmacological regulation of high-frequency rhythms of the behavioral activity (with a period of up to 1/2 hour) is an actual direction of modern medical science. The aim of the study was to assess the influence of oligopeptides structurally related to oxytocin on the parameters of ultradian rhythms of locomotor activity (LA) in outbred ICR laboratory mice. LA was recorded automatically in a multichannel actometer (Ugo Basile, Italy) in the conditions of individual detection. Amplitude, acrophase, and mesor of biorhythms’ were determined by the Cosinor analysis. Oligopeptides structurally related to oxytocin fragments, as well as memantine under systemic (intraperitoneal) administration, had a pronounced influence on the ultradian LA biorhythms of mice. Memantine (10.0 mg/kg), Cyclo-(Leu-Gly) (0.025 mg/kg), Pro-Leu (0.5 mg/kg), and Leu-Gly (0.1 mg/kg) triggered the migration to the right of the acrophase of statistically significant 24-minute LA rhythms versus control. A further study of the peptidergic mechanisms of regulation of fluctuations in ultradian biorhythms can contribute to the development of the theoretical foundations of chronobiology, as well as to the search for the means correcting the desynchronoses.
About the Authors
E. V. Kravchenko
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Kravchenko Elena V., Ph. D. (Biology), Leading researcher
5/2, Kuprevich Str., 220141, Minsk
N. A. Bizunok
Belarus State Medicinal University
Belarus
Belarus
Bizunok Natalia A, D. Sc. (Medicine), Professor, Head of the Department
83, Dzerzhinskiy Ave., 220116, Minsk
B. V. Dubovik
Belarus State Medicinal University
Belarus
Belarus
Dubovik Boris V., D. Sc. (Medicine), Professor
83, Dzerzhinskiy Ave., 220116, Minsk
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