Expression features of the elastogenesis markers in the invasive ductal breast cancer tissue before and after chemotherapy
https://doi.org/10.29235/1561-8323-2022-66-2-217-222
Abstract
The aim of the study is to analyze the changes in the elastic fibers and the expression features of elastinbinding protein-1, lysyl oxidase-1, and tetraspanin CD151 in the invasive ductal breast cancer tissues before and after chemotherapy courses. The study included 34 patients with invasive ductal breast cancer. The patients were divided into two groups: the first group had surgical resection of the tumor before chemotherapy, and the second group had surgical resection of the residual tumor after neoadjuvant chemotherapy. The frequency of elastic fibers accumulations around the ducts in patients without chemotherapy was significantly higher (61.1 %) than that in patients after neoadjuvant chemotherapy (25.0 %). After chemotherapy, the expression of elastin-binding protein-1 changed: the proportion of patients with a strong expression of this protein in tumor cells after chemotherapy increased (62.5 %) in comparison to patients without chemotherapy (16.8 %). The combined cytoplasmic and/or membrane expression of elastin-binding protein-1 in the tumor cells predominated in the second group compared with diffuse cytoplasmic expression (55.0 %) in tumor cells of patients of the first group.
Supporting agencies: The research is carried out within the framework of the BRFF agreement (Project М19М-034)
About the Authors
M. A. Korneeva
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Korneeva Marina A. – Ph. D. (Biology), Senior Researcher
28, Akademicheskaya Str., 220072, Minsk
I. A. Siamionik
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Siamionik Irina A. – Ph. D. (Biology), Senior Researcher
28, Akademicheskaya Str., 220072, Minsk
S. N. Rjabceva
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Rjabceva Svetlana N. – Ph. D. (Medicine), Head of the Laboratory
28, Akademicheskaya Str., 220072, Minsk
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