Angiogenic and antinociceptive effects of the genotherapy construction pcDNA_VEGF165 in the conditions of chronic limb ischemia in an in vivo experiment
https://doi.org/10.29235/1561-8323-2024-68-2-138-147
Abstract
For the first time, an in vivo experiment has established a positive combined (angiogenic and antinociceptive) effect of using the domestic genetically engineered construction pcDNA_VEGF165 under conditions of simulated limb muscle ischemia. A plasmid with a gene encoding the protein VEGF165 (pcDNA_VEGF165) may be the basis for creating the first gene therapy drugs in the Republic of Belarus.
About the Authors
V. G. Bogdan
Department of Medical Sciences of the National Academy of Sciences of Belarus
Belarus
Belarus
Vasiliy G. Bogdan – D. Sc. (Medicine), Professor, Academician-Secretary
66, Nezavisimosti Ave., 220072, Minsk
A. S. Doronkina
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Anastasya S. Doronkina – Researcher
28, Akademicheskaya Str., 220072, Minsk
I. P. Zhavoronok
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Irina P. Zhavoronok – Ph. D. (Biology), Head of the Сenter
28, Akademicheskaya Str., 220072, Minsk
E. V. Fedorova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Ekaterina V. Fedorova – Researcher
28, Akademicheskaya Str., 220072, Minsk
T. A. Filippovich
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Tatsiana A. Filipovich – Senior Researcher
28, Akademicheskaya Str., 220072, Minsk
S. G. Lepeshko
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Stanislav G. Lepeshko – Junior Researcher
28, Akademicheskaya Str., 220072, Minsk
S. V. Mankovskaya
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Svetlana V. Mankovskaya – Deputy Director
28, Akademicheskaya Str., 220072, Minsk
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