Prevalence of serine carbapenemase genes among multi-resistant strains of Klebsiella pneumoniae isolated from patients in the departments of surgery and intensive care units
https://doi.org/10.29235/1561-8323-2024-68-2-148-155
Abstract
The frequency of serine carbapenemases in phenotypically multi-drug resistant K. pneumoniae obtained from patients of surgery and intensive care units in Belarus was assessed. Beta-lactamase genes KPC, OXA-48, OXA-23, and OXA-24 were detected by PCR in 115 phenotypically multi-drug resistant K. pneumoniae. The most common carbapenemase gene was blaOXA-48 (70 %). The genes KPC and blaOXA-24 were identified in 43.6 and 39.1 % isolates, respectively. Single serine carbapenemase gene was detected in 23.5 % strains. On other strains, the molecular analysis determined double or triple carbapenemase gene combinations.
About the Authors
O. O. Yanovich
Republican Research and Practical Center for Epidemiology and Microbiology
Belarus
Belarus
Olga O. Yanovich – Ph. D. (Biology), Leading Researcher
23, Filimonov Str., 220114, Minsk
L. P. Titov
Republican Research and Practical Center for Epidemiology and Microbiology
Belarus
Belarus
Leonid P. Titov – Academician, D. Sc. (Medicine), Professor, Head of the Laboratory
23, Filimonov Str., 220114, Minsk
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