Quantum entangle in a zinc ion pair of RNA-dependent RNA polymerase of flaviviruses and its role in the polymerization reaction
https://doi.org/10.29235/1561-8323-2024-68-5-365-372
Abstract
The flavivirus polymerase protein undergoes structural changes during the polymerization reaction. The protein contains two zinc atoms, each of which is coordinated by four amino acids of the protein. The possibility of a quantum transition in zinc atoms is considered. It is shown that due to quantum entanglement this transition occurs jointly in both atoms. Using molecular dynamics modeling, it is shown that small perturbations of the structure associated with the joint transition of zinc atoms lead to structural changes in the polymerase. The prevalence of this phenomenon on other zinc-containing proteins is discussed.
About the Authors
U. V. Potapova
Belarusian State Technological University
Belarus
Belarus
Ulyana V. Potapova – Assistant, Belarusian State Technological University.
13a, Sverdlov Str., 220006, Minsk
S. I. Feranchuk
Belarus
Sergey I. Feranchuk – Ph. D. (Physics and Mathematics).
A. V. Batyanovskii
United Institute of Informatics Problems of the National Academy of Sciences of Belarus
Belarus
Belarus
Alexander V. Batyanovskii – Ph. D. (Physics and Mathematics), Senior Researcher, United Institute of Informatics Problems of the National Academy of Sciences of Belarus.
6, Surganov Str., 220012, Minsk
D. S. Matuskov
Belarusian State Technological University
Belarus
Belarus
Dmitry S. Matuskov – Student, Belarusian State Technological University.
13a, Sverdlov Str., 220006, Minsk
I. D. Feranchuk
Belarusian State University
Belarus
Belarus
Ilya D.Feranchuk – D. Sc. (Physics and Mathematics), Professor. Belarusian State University.
4, Nezavisimosti Ave., 220030, Minsk
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