Changes in the content of dopamine, serotonin, their precurrents and derivatives in the prefrontal cortex of the brain of young male rats under chronic exposure to low-intense electromagnetic field

The content of a number of biogenic amines, their precursors, and derivatives was studied in the prefrontal cortex (PFC) of the brain of male Wistar rats exposed to chronic exposure to a low-intensity electromagnetic field of a Wi-Fi device (24 hours/day, 2.45 GHz, the power flux density did not exceed 583 μW/cm², amounting to average – 0.46 ± 0.37 µW/cm²) during their early postnatal development. Changes in the content of dopamine, serotonin, their precursors, and metabolites in the PFC of the brain have been established, which determines the development of neurotransmitter disorders in the central nervous system, and subsequently the occurrence of behavioral disorders, the deterioration of social adaptation and cognitive abilities. The identified changes in the dopaminergic system of the PFC of the brain in rats at the early stages of their postnatal development indicate the need for a further hygienic assessment of the safety of long-term exposure to electromagnetic radiation on the body, especially on the brain. Further research in this direction will make it possible to determine neurotransmitter mechanisms underlying the adverse effects of low-intensity electromagnetic fields on the central nervous system, to assess their danger, and to correct the existing maximum permissible levels of electromagnetic radiation, taking into account the reaction of the neurotransmitter systems of brain structures to this type of impact.

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