Effect of lithium salts on functional activity and expression of P-glycoprotein in human lymphocytes in vitro
https://doi.org/10.29235/1561-8323-2025-69-6-498-503
Abstract
The effect of pharmacological and toxic concentrations of lithium salts (sulfate and chloride) on the expression and functional activity of the transporter protein P-glycoprotein (P-gp) in human lymphocytes in vitro was studied. It was found that in lymphocytes exposed to both lithium chloride and sulfate in the concentration range from 3 to 10 mM, inhibition of the functional activity of the membrane transporter P-gp occurs, and this effect depended on both the specific type of salt and its exposure concentration. A multidirectional effect on P-gp expression was found (an increase when cells were exposed to 10 mM lithium sulfate and no changes at the same concentration of lithium chloride), indicating the possible involvement of specific signaling pathways that are activated or inhibited depending on the anion, and not just the lithium cation. The results obtained are planned to be used in the future to create a method for assessing lithium toxicity for monitoring lithium concentrations in the blood.
Supporting agencies: The work was carried out with the financial support of the Belarusian Republican Foundation for Fundamental Research (grant Б23-107).
About the Authors
G. P. Zubritskaya
Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus
Belarus
Belarus
Zubritskaya Galina P. – Ph. D. (Biology), Associate Professor, Leading Researcher
27, Akademicheskaya Str., 220072, Minsk
E. I. Slobozhanina
Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus
Belarus
Belarus
Slobozhanina Ekaterina I. – Corresponding Member, D. Sc. (Biology), Professor, Chief Researcher
27, Akademicheskaya Str., 220072, Minsk
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