RUNX3 GENE METHYLATION AS A PROGNOSTIC FACTOR IN NON-MUSCLE-INVASIVE BLADDER CANCER
Abstract
The analysis of the RUNX3 gene methylation status was conducted in the prospective group of 262 bladder cancer patients. In comparison to normal urothelium, a high frequency (63 %) of RUNX3 promoter hypermethylation was observed in tumor tissues. А statistically significant association of RUNX3 epigenetic abnormalities with a more aggressive tumor phenotype – an advanced tumor stage and grade, as well as a large tumor size – was found. We have shown that RUNX3 hypermethylation is an independent risk factor for progression and cancer-specific survival in the group of patients with non-muscle invasive bladder cancer.
About the Authors
M. P. SMAL
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
A. I. ROLEVICH
N. N. Alexandrov National Cancer Center of Belarus, Lesnoy
Belarus
Belarus
T. I. NABEBINA
N. N. Alexandrov National Cancer Center of Belarus, Lesnoy
Belarus
Belarus
S. A. KRASNY
N. N. Alexandrov National Cancer Center of Belarus, Lesnoy
Belarus
Belarus
R. I. GONCHAROVA
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
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