Preview

Doklady of the National Academy of Sciences of Belarus

Advanced search

RUNX3 GENE METHYLATION AS A PROGNOSTIC FACTOR IN NON-MUSCLE-INVASIVE BLADDER CANCER

Abstract

The analysis of the RUNX3 gene methylation status was conducted in the prospective group of 262 bladder cancer patients. In comparison to normal urothelium, a high frequency (63 %) of RUNX3 promoter hypermethylation was observed in tumor tissues. А statistically significant association of RUNX3 epigenetic abnormalities with a more aggressive tumor phenotype – an advanced tumor stage and grade, as well as a large tumor size – was found. We have shown that RUNX3 hypermethylation is an independent risk factor for progression and cancer-specific survival in the group of patients with non-muscle invasive bladder cancer.

Views: 1036


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1561-8323 (Print)
ISSN 2524-2431 (Online)