FABRICATION AND PROPERTIES OF MIRAMISTIN-CONTAINING CALCIUM PECTINATE MICROPARTICLES
Abstract
Calcium pectinate microparticles with a hydrodynamic diameter of 2–6 μm were synthesized by the spray drying technique. The approach allowing one to entrap in them up to 30 wt. % of miramistin has been developed. It has been shown that all miramistin entrapped in microparticles fully releases in 2 hours in the acidic medium (pH 2.0). In the physiological solution, about 66 % of miramistin releases in 48 hours. In the alkali solution, less than 5 % of miramistin releases in 2 days.
About the Authors
V. I. KULIKOUSKAYA
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
D. I. EGOROV
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
V. Е. AGABEKOV
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
References
1. Song, Y. B. α-Tocopherol-loaded Ca-pectinate microcapsules: optimization, in vitro release and bioavailability / Y. B. Song, J. S. Lee, H. G. Lee // Colloids and Surfaces B: Biointerfaces. – 2009. – Vol. 73, N 2. – P. 394–398.
2. Sriamornsak, P. Application of pectin in oral drug delivery / P. Sriamornsak // Expert Opinion on Drug Delivery. – 2011. – Vol. 8, N 8. – P. 1009–1023.
3. Ogaji, I. J. Advances in natural polymers as pharmaceutical excipients / I. J. Ogaji, E. I. Nep, J. D. Audu-Peter // Pharm. Anal. Acta. – 2011. – Vol. 3, N 1. – P. 146.
4. Потиевский, Э. Г. Медицинские аспекты применения пектина / Э. Г. Потиевский, А. И. Новиков. – М.: Мед. книга, 2002.
5. Получение полимерных микрочастиц с биологически активными веществами методом распылительной сушки (обзор литературы) / С. А. Кедик [и др.] // Вестн. ВГУ. Серия: Химия. Биология. Фармация. – 2014. – № 2. – С. 28–32.
6. Vehring, R. Pharmaceutical particle engineering via spray drying / R. Vehring // Pharm. Res. – 2008. – Vol. 25, N 5. – Р. 999–1022.
7. Thibault, J. F. Chain association of pectic molecules during calcium-induced gelation / J. F. Thibault, M. Rinaudo // Biopolymers. – 1986. – Vol. 25. – P. 455–468.
8. Григорьева, М. В. Полимерные системы с контролируемым высвобождением биологически активных соединений / М. В. Григорьева // Биотехнология. – 2011. – Т. 4, № 2. – С. 9–23.
Review
Views: 943
Email this article 