EXPERIMENTAL STUDY OF ALTERNATIVE WAYS OF STEM CELL DELIVERY INTO THE BRAIN
Abstract
In experiments on rats, the technique of application of mesenchymal cells into the region of the receptive or conductor paths of cranial nerves (I and V pair) was perfected for the natural movement of these cells to the central nucleus of the nerve, and then into the damaged areas of the brain. It is found that after the modeling of a local injury of the precentral gyrus, the mesenchymal cells implanted into the submucosa of the nasal cavity have been visualized in the olfactory bulb and in the damage area in 1 hour. After the pre-damaged areas of the cerebellar cortex, the mesenchymal cells introduced into the Meckel area are found in 1 hour in the central nuclei of the trigeminal nerve in the damage area.
About the Author
Y. P. STYKACH
Institute of Physiology of National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
References
1. Лосева, Е. В. Стволовые клетки для коррекции нейродегенеративных расстройств / Е. В. Лосева // Нейрокомпьютеры: разработка, применение. – 2013. – № 7. – С. 32–41.
2. Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review / L. T. Alvarim [et al.] // Int. J. Nanomedicine. – 2014. – N 9. – P. 3749–3770.
3. From Blood to the Brain: Can Systemically Transplanted Mesenchymal Stem Cells Cross the Blood-Brain Barrier? / L. Liu [et al.] // Stem. Cells Int. – 2013. – N 2013. – P. 435093.
4. Safety of human neural stem cell transplantation in chronic spinal cord injury / K. M. Piltti [et al.] // Stem. Cells Transl. Med. – 2013. – Vol. 2, N 12. – P. 961–974.
5. SDF-1α/CXCR4 Axis Mediates The Migration of Mesenchymal Stem Cells to The Hypoxic-Ischemic Brain Lesion in A Rat Model / Q. Yu [et al.] // Cell J. – 2015. – Vol. 16, N 4. – P. 440–447.
6. Detection of mouse endogenous type B astrocytes migrating towards brain lesions / G. Elvira [et al.] // Stem Cell Research. – 2015. – Vol. 14, N 1. – P. 114–129.
7. Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1 / P. P. Garcez [et al.] // Nat. Commun. – 2015. – Vol. 6. – P. 6474.
8. Intranasal Delivery of Neural Stem Cells: A CNS-specific, Non-invasive Cell-based Therapy for Experimental Autoimmune Encephalomyelitis / S. Wu [et al.] // J. Clin. Cell Immunol. – 2013. – Vol. 4, N 3. – P. 10.4172/2155-9899.1000142.
9. Intranasal delivery of neural stem/progenitor cells: a noninvasive passage to target intracerebral glioma / M. Sreitz [et al.] // Stem Cells Transl. Med. – 2012. – Vol. 1. – P. 866–873.
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