GENE POLYMORPHISM OF AROMATASE IN PATIENTS WITH SEROUS OVARIAN CANCER IN THE REPUBLIC OF BELARUS
Abstract
The aim of the present research was to study the frequency of the distribution of variants of gene polymorphism of aromatase (СYP19A1) in Belarusian patients with serous ovarian cancer. This population established the influence of gene polymorphism rs10046 with the risk of serous ovarian cancer in women older than 50 years: CT genotype in a group of patients with serous ovarian cancer was met significantly less than in the control group (OR = 0.58; 95 % CI: 0.37–0.91; p = 0.023).
About the Authors
А. P. MIKHALENKA
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
S. E. SHELKOVICH
Belarusian Medical Academy of Post-Graduate Education, Minsk
Belarus
Belarus
N. V. CHEBOTAREVA
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
A. N. SCHAYUK
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
E. N. MAISENIA
Minsk City Clinical Oncologic Dispensary, Minsk, Belarus
Belarus
Belarus
Yu. E. DEMIDCHIK
Belarusian Medical Academy of Post-Graduate Education, Minsk
Belarus
Belarus
E. V. KRUPNOVA
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
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