REGULATION OF CA2 +-SIGNALING IN NEUTROPHILS BY MYELOPEROXIDASE
Abstract
It is shown that myeloperoxidase (MPO) initiates an increase in the concentration of intracellular free calcium ions in neutrophils caused both by the release of calcium ions from intracellular stores, and extracellular Ca2+ entry across the plasma membrane channels. It is found that MPO modified by hypohalous acids retains its ability to induce Ca2+-signaling in neutrophils. It is established that MPO-induced entry of Ca2+ into cytosol of neutrophils is not associated with its catalytic activity, but caused by direct binding of MPO to α-subunit of β2-integrin of neutrophils and tyrosine kinase activation.
About the Authors
D. V. GRIGORIEVA
Белорусский государственный университет, Минск
Belarus
Belarus
I. V. GORUDKO
Белорусский государственный университет, Минск
Belarus
Belarus
A. V. SOKOLOV
НИИ экспериментальной медицины СЗО РАМН, Санкт-Петербург
Russian Federation
Russian Federation
E. V. SHAMOVA
Белорусский государственный университет, Минск
Belarus
Belarus
V. B. VASILIEV
Санкт-Петербургский государственный университет
Russian Federation
Russian Federation
O. M. PANASENKO
НИИ физико-химической медицины ФМБА России, Москва
Russian Federation
Russian Federation
S. N. CHERENKEVICH
Белорусский государственный университет, Минск
Belarus
Belarus
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