ONE-STEP METHOD FOR OBTAINING THE DERIVATIVES OF 2-ARYLAMINOPYRIMIDINE ASSOCIATES WITH MAGNETITE
Abstract
A one-step method for preparing associates of magnetite nanocarriers with bioactive 2- rylaminopyrimidine derivatives containing the pharmacophore fragments of protein kinase inhibitors and SH-group was developed. The feature of the method is the presence of dimethyl sulfoxide and 2-arylaminopyrimidines in the medium of formation of magnetite nanoparticles
About the Authors
А. V. PIETKIEVICH
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Zh. V. IGNATOVICH
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
E. V. KOROLEVA
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
A. N. ERYOMIN
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
V. E. AGABEKOV
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
References
1. Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy / G. Chen [et al.] // Chem. Rev. – 2016 – Vol. 116. N 5. – P. 2826–2885.
2. Thanh, N. T. K. Functionalisation of nanoparticles for biomedical applications / N. T. K. T hanh, L . A. W. G reen // Nano Today. – 2010 – Vol. 5, N 3. – P. 213–230.
3. Производные аминопиримидина как ингибиторы протеинкиназ. Молекулярный дизайн, синтез и биологическая активность / Е. В. Королева [и др.] // Журн. орган. химии. – 2016 – Т. 52, № 2. – С. 159–196.
4. Получение и свойства ассоциатов наночастиц золота с 4-(меркаптометил)-N-[4- метил-3{4-(пиридин-3-ил)- пиримидин-2-иламино}фенил] бензамидом / А. В. Абакшонок [и др.] // Докл. НАН Беларуси. – 2013. – Т. 57, № 6. – С. 52–56.
5. Ассоциация амидов 2-ариламинопиримидина и фолиевой кислоты с композитными наночастицами на основе сульфида цинка и магнетита / А. В. Абакшонок [и др.] // Весцi НАН Беларусi. Сер. хiм. навук. – 2015. – № 2. – С. 72–81.
6. Synthesis of N-[2(3,4)-aminophenyl]-4-({4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2- ylamino]phenyl}aminomethyl)- benzamides / Zh. V. Ignatovich [et al.] // Russ. J. Org. Chem. – 2015. – Vol. 51, N 10. – P. 1449–1452.
7. Resolving the Structure of Ligands Bound to the Surface of Superparamagnetic Iron Oxide Nanoparticles by High- Resolution Magic-Angle Spinning NMR Spectroscopy / L. Polito [et al.] // J. Am. Chem. Soc. – 2008. – Vol. 130, N 38. – P. 12712–12724.
8. Illés, E. The effect of humic acid adsorption on pH-dependent surface charging and aggregation of magnetite nanoparticles / E. Illés, E. Tombácz // J. Colloid and Interface Science. – 2006. – Vol. 295, N 1. – P. 115–123.
9. Сидельковская, Ф. П. Химия N-винилпирролидона и его полимеров / Ф. П. Сидельковская. – М.: Наука, 1970. – 150 с.
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