DEGREE OF COLONIZATION BY PATHOGENIC AND OPPORTUNISTIC MICROORGANISMS AS A PROGNOSTIC FACTOR OF THE SEPSIS DEVELOPMENT
Abstract
The development of sepsis in newborns with congenital malformations of the gastrointestinal tract in the postoperative period depends on the colonization of various biotopes. The starting etiological factors are: the presence of opportunistic and pathogenic microflora in certain biotopes, as well as a quantitative content of microorganisms (the “degree of microbial load”). It has been established that colonization of biotopes with a quantitative assessment of CFU of 104 /g (colony forming unit) and more is one of the factors of the sepsis development in newborns with this pathology.
About the Authors
Aleksandr V. SukaloBelarus
Academician, D. Sc. (Medicine), Professor, Head of the Department
83, Dzerzhynskiy Ave., 220116
Vladimir I. Volkov
Belarus
anesthesiologistresuscitator
64, Nezavisimosti Ave., 220013
References
1. Vasil’tseva A. P. Modern state-of-art-of the sepsis problem. Therapeutic aspects. Minsk, 2013. 254 p. (in Russian).
2. Minaev S. V., Kirgizov I. V., Obedin A. N., Isaeva A. V., Bolotov Yu. N., Tovkan E. A., Lukyanenko E. V., Khoranova T. A., Timofeev S. I., Gudiev Ch. G., Getman N. V. Monitoring of inflammatory complications development in the newborns with congenital pathology of the gastrointestinal tract. Meditsinskii vestnik Severnogo Kavkaza = Medical News of North Caucasus, 2013, vol. 8, no. 2, pp. 30–33 (in Russian).
3. Obedin A. N., Minaev S. V. Zonulin as a forecasting marker of inflammatory complications after surgery at newborns with congenital intestinal tract development malformations. Vestnik novykh meditsinskikh tekhnologii = Journal of New Medical Technologies, 2011, vol. 18, no. 4, pp. 82–84 (in Russian).
4. Obedin A. N., Minaev S. V., Kirgizov I. V., Aleksandrov A. E., Tovkan E. A., Romaneeva N. M., Khoranova T. A., Tchitaeva L. A. The importance of the risk factors of purulent-septic complications development. Current pediatrics, 2012, vol. 11, no. 4, pp. 90–94 (in Russian). doi.org/10.15690/vsp.v11i4.364
5. Telyatitskii N. I., Abaev Yu. K. Nosocominal infect of newborns. Meditsinskii zhurnal = Medical Journal, 2010, no. 2, pp. 27–32 (in Russian).
6. Shishko G. A., Kurek V. V., Ustinovich Yu. A., Mironov L. L., Krasteleva I M., Sapotnitskii A. V., Goretaya S. P., Koval’ S. N. Sepsis of newborns. Minsk, BelMAPO Publ., 2012. 55 p. (in Russian).
7. Congenital malformations. Report of the WHO Secretariat. – 2016. Available at: www.who.Int/entity/healthinfo/ statistics/2016.
8. Aneja R. K., Varughese-Aneja R., Vetterly C. G., Carcillo J. A. Antibiotic therapy in neonatal and pediatric septic shock. Current Infectious Disease Reports, 2011, vol. 13, no. 5, pp. 433–441. doi.org/10.1007/s11908-011-0197-5
9. Mitul A. R. Surgical neonatal sepsis in developing countries. Journal of Neonatal Surgery, 2015, vol. 4, no. 4. pp. 41.
10. Fioretto J. R., Martin J. G., Kurokawa C. S., Carpi M. F., Bonatto R. C., de Moraes M. A., Ricchetti S. M. Comparison between procalcitonin and C-reactive protein for early diagnosis of children with sepsis or septic shock. Inflammation Research, 2010, vol. 59, no. 8, pp. 581–586. doi.org/10.1007/s00011-010-0161-0
11. Riley C., Wheeler D. S. Prevention of Sepsis in Children: A New Paradigm for Public Policy. Critical Care Research and Practice, 2012, vol. 2012. 8 p. doi.org/10.1155/2012/437139
12. American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. Critical Care Medicine, 2017, vol. 45, no. 6, pp. 1061–1093. doi: 10.1097/CCM.0000000000002425