PREPARATION AND PROPERTIES OF KANAMYCIN-CONTAINING HYDROGELS BASED ON PECTIN-Ag NANOCOMPOSITE
https://doi.org/10.29235/1561-8323-2018-62-4-432-438
Abstract
The hydrogels based on nanocomposite pectin-Ag exhibiting the antibacterial activity (MIСAg = 0.02–0.81 mM) were obtained by ionotropic gelation. It was shown that the synthesized hydrogels had a high capacity for kanamycin (up to 70 wt. %). The obtained hydrogels provided a prolonged release of kanamycin in 0.9 % NaCl and enhanced its antibacterial activity (MIC decreased 10–20 times) due to the synergistic effect.
Supporting agencies: The work was supported by the Belarusian Republican Foundation for Fundamental Research (Project no. Х16-057).
About the Authors
Kseniya S. Hileuskaya
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Hileuskaya Kseniya Sergeevna – Ph. D. (Chemistry), Senior researcher
36, F. Skoryna Str., 220141, Minsk
Aliaksandr N. Kraskouski
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Kraskouski Aliaksandr Nikolaevich – Junior researcher
36, F. Skoryna Str., 220141, Minsk
Alena I. Ladutska
Institute of Microbiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Ladutska Alena Ivanovna – Ph. D. (Biology), Leading Researcher
2, Kuprevich Str., 220141, Minsk
Galina I. Novik
Institute of Microbiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Novik Galina Ivanovna – Ph. D. (Biology), Head of the Laboratory
2, Kuprevich Str., 220141, Minsk
Vladimir E. Agabekov
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Agabekov Vladimir Enokovich – Academician, D. Sc. (Chemistry), Professor, Director
36, F. Skoryna Str., 220141, Minsk
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