Structural and physico-chemical transformations of modified with epoxy resin pericardia implants
https://doi.org/10.29235/1561-8323-2018-62-6-703-711
Abstract
Bovine pericardium samples modified with ethylene glycol diglycidyl ether, designed for surgical correction of congenital heart defects and large blood vessels, were studied by scanning electron microscopy, X-ray diffraction, IR spectroscopy, and differential thermal analysis. It was found that the initial samples of pericardium, before implantation, contain sites of disorganization of the collagen matrix, fragile fracture of collagen fibrils and destruction of the interstitial membranes promoting the penetration of immunocytes into the deep layers of the pericardium. Ossifying calcification with amorphized hydroxyapatite deposition and bone tissue formation as well as multiple erosions and hypertrophic proliferation in the endothelial membrane were detected in the implantation pericardium samples.
About the Authors
A. A. Gaidash
Republican Research and Practical Center for Pediatric Surgery, Minsk
Belarus
D. Sc. (Medicine), Professor, Chief research
Belarus
D. Sc. (Medicine), Professor, Chief research
A. I. Kulak
Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Corresponding Member, D. Sc. (Chemistry), Professor, Director
Belarus
Corresponding Member, D. Sc. (Chemistry), Professor, Director
K. V. Drozdovski
Republican Research and Practical Center for Pediatric Surgery, Minsk
Belarus
Ph. D. (Medicine), Director
Belarus
Ph. D. (Medicine), Director
V. V. Kazbanov
Republican Research and Practical Center for Pediatric Surgery, Minsk
Belarus
Scientific secretary
Belarus
Scientific secretary
V. K. Krut’ko
Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Ph. D. (Chemistry), Assistant professor, Leading researcher
Belarus
Ph. D. (Chemistry), Assistant professor, Leading researcher
O. N. Musskaya
Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Ph. D. (Chemistry), Assistant professor, Senior researcher
Belarus
Ph. D. (Chemistry), Assistant professor, Senior researcher
Yu. I. Linnik
Republican Research and Practical Center for Pediatric Surgery, Minsk
Belarus
cardiac surgeon
Belarus
cardiac surgeon
K. V. Skrotskaya
Research Institute for Physical Chemical Problems of the Belarusian State University, Minsk
Belarus
engineer
Belarus
engineer
References
1. Corno A. F., Hurni M., Griffin H., Galal o. M., Payot M., Sekarski N., Tozzi P., von Segesser l. k. Bovine jugular vein as right ventricle-to-pulmonary artery valved conduit. Journal of Heart Valve Disease, 2002, vol. 11, no. 2. pp. 242–247.
2. Breymann T., Thies W. R., Boethig D., Goerg R., Blanz U., koerfer R. Bovine valved venous xenografts for RVoT reconstruction: results after 71 implantations. European Journal of Cardio-Thoracic Surgery, 2002, vol. 21, no. 4, pp. 703– 710. https://doi.org/10.1016/s1010-7940(02)00049-0
3. Chesnov yu. M. Structure and biocompatibility of the pericardium fixed by epoxy compounds in the experiment. Zdravoohranenie [Health care], 2005, no. 5, pp. 5–9 (in Russian).
4. Astapov D. A., karaskov A. M., kim M. V., Semenova E. I., Demidov D. P. long-term results of tricuspid valve replacement with biological prostheses: a retrospective study. Tihookeanskiy meditsinskiy zhurnal [Pacific Medical Journal], 2013, no. 3, pp. 41−44 (in Russian).
5. Chesnov yu. M., ostrovsky yu. P., Skornyakov V. I., Dergachev A. V., Shved M. M. Development and clinical experience of the use of biological patches «Biocard» in cardiovascular surgery. Meditsinskaya panorama [Medical panorama], 2005, no. 3, pp. 20–22 (in Russian).
6. Chesnov yu. M., ostrovsky yu. P., Skornyakov V. I., Dergachev A. V., Shved M. M. Application of biological patches «Biocard» in cardiovascular surgery. Meditsinskie novosti [Medical news], 2006, no. 3, pp. 137–140 (in Russian).
7. Tsuber V. k., lesnikovich l. A., kulak A. I., Trofimova I. V., Petrov P. T., Trukhacheva T. V. , kovalenko yu. D., krasil’nikova V. l. Synthesis, identification and determination of impurities in bioactive hydroxyapatite. Pharmaceutical Chemistry Jourmal, 2006, vol. 40, no. 8, pp. 455–458. https://doi.org/10.1007/s11094-006-0151-2
8. krut’ko V. k., kulak A. I., Musskaya o. N. Thermal Transformations of Composites Based on Hydroxyapatite and Zirconia. Inorganic Materials, 2017, vol. 53, no. 4, pp. 429–436. https://doi.org/10.1134/s0020168517040094
9. Musskaya o. N., kulak A. I., krut’ko V. k., lesnikovich yu. A., kazbanov V. V., Zhitkova N. S. Preparation of Bioactive Mesoporous Calcium Phosphate Granules. Inorganic Materials, 2018, vol. 54, no. 2, pp. 117–124. https://doi. org/10.1134/s0020168518020115
10. limanskaya A. yu., Averin I. A. Study of blood vessels of the human cardiovascular system using an IR-Fourier spectrometer and analysis of infrared spectra. Molodoy uchenyiy [Young Scientist], 2015, vol. 1, no. 81, pp. 44–47 (in Russian).
11. Dzhatdoeva A. A., Polimova A. M., Proskurnina E. V., Proskurnin M. A., Vladimirov yu. A. Determination of lipids and Their oxidation Products by IR Spectrometry. Journal of Analytical Chemistry, 2016, vol. 71, no. 6, pp. 542–548. https:// doi.org/10.1134/s1061934816060058
12. Germaini M. M., Detsch R., Grünewald A., Magnaudeix A., lalloue F., Boccaccini A. R., Champion E. osteoblast and osteoclast responses to A/B type carbonate-substituted hydroxyapatite ceramics for bone regeneration. Biomedical Materials, 2017, vol. 12, no. 3, pp. 035008. https://doi.org/10.1088/1748-605x/aa69c3
13. lee J. M., Pereira C. A., Abdulla D., Naimark W. A., Crawford I. A multi-sample denaturation temperature tester for collagenous biomaterials. Medical Engineering & Physics, 1995, vol. 17, no. 2, pp. 115–121. https://doi.org/10.1016/1350-4533(95)91882-h
14. de Batista T. M., Martins V. C. A., de Guzzi Plepis A. M. Thermal behavior of in vitro mineralized anionic collagen matrices. Journal of Thermal Analysis and Calorimetry, 2009, vol. 95, no. 3, pp. 945–949. https://doi.org/10.1007/s10973-007-8897-7
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