Influence of the extracorporeal detoxication methods on the levels of nonessential amino acids in the blood plasma of patients with sepsis (Communicated by Corresponding Member Nikolay S. Serduchenko)
https://doi.org/10.29235/1561-8323-2020-64-4-457-465
Abstract
Some disadvantages of the extracorporeal blood purification (EBP) methods as reducing plasma levels of different important metabolites are described. Disorders of amino acid metabolism in sepsis are manifested into microcirculation interruptions, a decreased immune response and an increased mortality. The aim of the study is to investigate the EBP influence on the levels of nonessential amino acids in the blood plasma of patients with sepsis. 28 patients diagnosed with “sepsis” were selected. Standard treatment protocols of plasma filtration, hemofiltration and hemadsorption with various sorbents were used. A significant decrease in the levels of asparagine, phosphoethanolamine, proline; α-aminobutyric acid showed a significant increase in these levels in patients who underwent “Proteasosorb” sorbent hemadsorption. A significant decrease in the levels of ornithine, aspartic acid, 3-methylhistidine, 1-methylhistidine in patients treated with hemofiltration was found. The EBP methods significantly influence the amino acid metabolism.
About the Authors
R. E. Yakubtsevich
Grodno State Medical University
Belarus
Belarus
Yakubtsevich Ruslan E. - D. Sc. (Medicine), Associate professor, Head of the Department, Grodno State Medical University.
80, Gorky Str., 230009, Grodno.
N. V. Belyavsky
Grodno Regional Clinical Hospital
Belarus
Belarus
Belyavsky Nickolay V. - Anesthesiologist-rheanimatologist, Grodno Regional Clinical Hospital.
52, Leninsky Komsomol Boulevard, 230030, Grodno.
A. A. Glazev
Yanka Kupala Grodno State University
Belarus
Belarus
Glazev Anton A. - Ph. D. (Biology), Deputy Vice-Rector, Yanka Kupala Grodno State University.
22, Ozheshko Str., 230023, Grodno.
S. D. Klisa
Yanka Kupala Grodno State University
Belarus
Belarus
Klisa Sergey D. - Junior researcher, Yanka Kupala Grodno State University.
22, Ozheshko Str., 230023, Grodno.
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