Estimation of the selectivity of sorbents for IgG binding based on tripeptide ligands
https://doi.org/10.29235/1561-8323-2021-65-3-303-308
Abstract
Biospecific sorbents for the removal of IgG and subclasses from biological fluids based on oligopeptides, containing aromatic amino acid residues, were created. The selectivity properties of specific sorbents for IgM, IgE, and plasma proteins were evaluated. It was found that the created sorbents exhibit the low activity to the total plasma protein, albumin, IgM, IgE and are highly specific for IgG.
About the Authors
Y. S. Pustsyulga
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Pustyulga Yegor S. – Researcher
5/2, Kuprevich Str., 220141, Minsk, Republic of Belarus
O. V. Gribovskaya
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Gribovskaya Olga V. – Senior researcher
5/2, Kuprevich Str., 220141, Minsk, Republic of Belarus
E. M. Ermola
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Ermola Eugeny M. – Researcher
5/2, Kuprevich Str., 220141, Minsk, Republic of Belarus
V. P. Golubovich
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Golubovich Vladimir P. – D. Sc. (Biology), Professor, Head of the Laboratory
5/2, Kuprevich Str., 220141, Minsk, Republic of Belarus
A. G. Moiseenok
Institute of Biochemistry of Biologically Active Compounds of the National Academy of Science of Belarus
Belarus
Belarus
Moiseenok Andrey G. – Corresponding Member, D. Sc. (Biology), Professor
50, Leninsky Komsomol boulevard, 230030, Grodno, Republic of Belarus
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