COMPUTER-AIDED SCREENING OF SMALL-MOLECULE HIV-1 ENTRY INHIBITORS BASED ON NEUTRALIZING ANTIBODY 10E8
Abstract
Computer-based screening of small-molecule HIV-1 entry inhibitors presenting potential peptidomimetics of broadly neutralizing monoclonal antibody 10E8 is carried out. Eight chemical compounds able to block the HIV-1 gp41 segment critical for fusion of the virus membrane with a target cell were identified using molecular modeling. These compounds
are considered as promising basic structures for the design of novel broad anti-HIV drugs
About the Authors
I. A. KASHYN
Институт биоорганической химии НАН Беларуси, Минск
Belarus
Belarus
A. V. TUZIKOV
Объединенный институт проблем информатики НАН Беларуси, Минск
Belarus
Belarus
A. M. ANDRIANOV
Институт биоорганической химии НАН Беларуси, Минск
Belarus
Belarus
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