MECHANISMS OF NONCOEZYME ACTION OF NEUROVASOTROPIN COMPONENTS DURING OXIDATIVE STRESS AND DEVELOPMENT OF ANTI-STRESS THIAMINE-CONTAINING DRUGS

Abstract

The substitution of cyanocobalamine for lipoic acid in the composition of immunotropic anti-stressin B (B₁+B₆+B₁₂), which was successfully tested in clinical sepsisology, resulted in the development of neurovasotropin, an antidiabetic drug with enhanced antioxidant capacity. During incubation of myoglobin in the presence of hydroperoxide, components of neurovasotropin (thiamine, lipoic acid, and to a lesser extent pyridoxal phosphate) inhibited the production of dimers of paracetamol and tyrosine, markers of oxidative stress indicating the level of free radical formation in the system in vitro. Further modification of neurovasotropin due to its incorporation in tyrosine (or substitution of the pyridoxine constituents for tyrosine) will result in the development of a new drug «homestasin» with probably more pronounced antioxidant properties, which is necessary for correction of different pathologies related to oxidative stress (myocardial infarction, cerebral stroke, etc).