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OXIDATIVE STRESS AS ONE OF THE POSSIBLE WAYS OF ANTICANCER EFFECTS OF BRASSINOSTEROIDS

Abstract

In this paper, the effect of brassinosteroids – 24-epibrassinolide and 28-homocastasterone, as well as their stereoisomers – (22S,23S)-24-homobrassinolide and (22S,23S)-28-homocastasterone on the level of reactive oxygen species in cancer cell line A549 (lung adenocarcinoma) has been characterized for the first time, and the results obtained have been compared with the data on their antiproliferative activity.
The effect depended on the structure of the side chain and was more pronounced in the case of the SS-orientation of hydroxyl groups at the C22 and C23 positions ((22S,23S)-28-homocastasterone). This compound also had greater antiproliferative activity, which suggested a possible relationship between the induction of activated oxygen species and cytotoxicity of the substances.
The results of this work allow one to assume that one of the ways of the effect of brassinosteroids on cancer cells may lie in the initiation of oxidative stress, which leads to the death of cancer cells through ROS-dependent mechanisms.

About the Authors

P. A. KISELEV
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus


O. V. PANIBRAT
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus


A. G. SYSA
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus


M. V. ANISOVICH
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus


V. N. ZHABINSKII
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus


V. A. KHRIPACH
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus


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ISSN 1561-8323 (Print)
ISSN 2524-2431 (Online)