PECULIARITIES OF MOLECULAR-GENETIC STRUCTURE OF PHAGE PF-10
Abstract
The analysis of a full nucleotide sequence of bacteriophage Pf-10 as a key constituent of biopesticide “Multiphage” has revealed that its unique genome is composed of a DNA fragment of broad range host phage Phi-S1, where the determinants governing the synthesis of early proteins are localized, and of the DNA fragment of narrow range host phage phiIBB-PF7A containing the genes responsible for the synthesis of late proteins. Low homology of individual genetic determinants and encoded amino acid sequences (namely, the genes determining the synthesis of tail proteins) with those of phages Phi-S1 or phiIBB-PF7A evidences the mutations that emerge in the course of the phage Pf-10 genome formation and are capable to affect its vital important functions.
About the Authors
T. A. Pilipchuk
Institute of Microbiology of the National Academy of Sciences of Belarus
Belarus
Researcher
Belarus
Researcher
L. N. Valentovich
Institute of Microbiology of the National Academy of Sciences of Belarus
Belarus
Ph. D. (Biology), Senior researcher
Belarus
Ph. D. (Biology), Senior researcher
M. A. Titok
Institute of Microbiology of the National Academy of Sciences of Belarus
Belarus
D. Sc. (Biology), Chief researcher
Belarus
D. Sc. (Biology), Chief researcher
E. I. Kolomiets
Institute of Microbiology of the National Academy of Sciences of Belarus
Belarus
Corresponding Member, D. Sc. (Biology), Director
Belarus
Corresponding Member, D. Sc. (Biology), Director
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