NEW APPROACHES TO THE DIAGNOSIS OF SIGMOID COLON CANCER OF PATIENTS WITH COLORECTAL CANCER BY THE DNA-PLOIDY CRITERION
Abstract
The DNA ploidy and molecular biological characteristics of adenocarcinoma of sigmoid colon by flow cytometry were studied. In 71 % of the patients, diploid was detected and in 29 % of the patients – aneuploid tumors. In the diploid tumor profile in the distribution of cell cycle phases, significant differences are revealed in the content of cells in G0 / G1 and S phases of the cell cycle, as compared to the aneuploid tumor profile. There is the increased DNA – the synthetic and proliferative activity of tumor cells compared to patients with the aneuploid tumor profile. Patients with the diploid tumor profile have a number of cells in the S phase 5 times more than in patients with the aneuploid tumor profile. It may be assumed that in patients with aneuploid sigmoid cancer, the recurrence rate is higher and the survival rate is lower than in those with the diploid tumor profile.
About the Authors
L. N. Nikolaevich
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Ph. D. (Biology), Assistant Professor, Head of the Laboratory
Belarus
Ph. D. (Biology), Assistant Professor, Head of the Laboratory
I. V. Zalutsky
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Corresponding Member, D. Sc. (Medicine), Professor, Director
Belarus
Corresponding Member, D. Sc. (Medicine), Professor, Director
I. V. Rudenkova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Junior researcher
Belarus
Junior researcher
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