CELLULOSE SULFATE ACETATE POLYMER COMPLEXES OF CEPHALOSPORINS
Abstract
The state-of the-art in antibiotics modification is the development of acid resistant dosage forms for per oral treatment. This article is about the synthesis of complexes of ceftriaxone and cefotaxime, 3rd generation antibiotics of cephalosporines family, with new water-soluble cellulose derivative – acetate sulfate sodium salt. The composition of complexes was established by UV- and FTIR-spectroscopy. Stable in acid media tablet dosage form of antibiotics was prepared by the immobilization of complexes on activated carbon. Release of the major quantity of antibiotics was proved by HPLC method to be in alkaline media modeling the intestine.
About the Authors
T. A. Savitskaya
Belarusian State University
Belarus
Ph. D. (Chemistry), Assistant professor, Professor of the Department
Belarus
Ph. D. (Chemistry), Assistant professor, Professor of the Department
K. A. Shakhno
Belarusian State University
Belarus
Postgraduate student
Belarus
Postgraduate student
A. S. Firaha
Belarusian State University
Belarus
Junior researcher
Belarus
Junior researcher
D. D. Grinshpan
Research Institute for Physical Chemical Problems of the Belarusian State University
Belarus
D. Sc. (Chemistry), Professor, Head of the Laboratory
Belarus
D. Sc. (Chemistry), Professor, Head of the Laboratory
O. A. Ivashkevich
Belarusian State University
Belarus
Academician, D. Sc. (Chemistry), Proffesor, First Vice-rector
Belarus
Academician, D. Sc. (Chemistry), Proffesor, First Vice-rector
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