ROLE OF ADRENORECEPTORS IN THE EFFECTS OF FAT ON THE ELECTRIC ACTIVITY OF THE STOMACH AND THE COLON
Abstract
The objective of the present work is to study the effects of fat and propranolol adrenoblocker on changes in the potentials of smooth muscles (PSM) of the stomach and the colon, impulsion of sympathetic fibres (ISF). Acute experiments on rats (anaestesia – 70 mg/kg of thiopental sodium, intraperitoneally) have been carried. It is found that a single introduction of olive oil into the duodenum (0.5 ml) results in a long increase of the amplitude of the PSM of pilorus and reciprocne – to falling in the colon. Simultaneously, the sympathetic inhibitory reaction occurs and the ISF in the mesenteric nerves of the candal part of the intestines is depressed. The preliminary hypodermic introduction of propranolol eliminates both those answers. After a long addition of olive oil (1 ml/day) to the feed, in 30 days the amplitude of the background PSMs of the pilorus considerably grows and there are no effects of the PSM increase on the action of propranolol and fat regularly arising in the control, but the colon potentials decrease for sure as in the case of a single introduction of the β-blocker. These data show that both single and long actions of the fat on interoceptors cause a stable suppression of the activity of β-adrenoreceptors of the stomach and intestines, thereof the tonic electric activity of the smooth muscles of these organs rises. It is supposed that the adrenoblocking effects of the fat consumed in large quantities on the motor function of the intestines are an important part of the peripheral mechanisms associated with the obesity.
About the Authors
V. V. Soltanov
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Corresponding Member, D. Sc. (Biology), Professor, Chief researcher
Belarus
Corresponding Member, D. Sc. (Biology), Professor, Chief researcher
L. M. Komarovskaya
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Researcher
Belarus
Researcher
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