SYNTHESIS OF FUNCTIONALLY SUBSTITUTED PYRIMIDINE DERIVATIVES BASED ON (E)-3- (4,5-DICHLOROISOTHIAZOL-3-YL)-1-FERROCENYLPROP-2-EN-1-ONE
Abstract
3-(4,5-Dichloroisothiazol-3-yl)-1-ferrocenylprop-2-en-1-one was synthesized by condensation of acetyl ferro-cene with 4,5-dichloroisothiazole-3-carbaldehyde. The reaction of isothiazolylferrocenyl ketone obtained with guanidine resulted in amino substituted ferrocenylisothiazolyl pyrimidine. The interaction of isothiazolylferrocenyl ketone with thiourea proceeded by heterocyclization, leading to the formation of ferrocenylisothiazolyl-3,4-dihydropyrimidin-2(1H)-thione. Hybrid derivatives of azaheterocycles and ferrocene are of interest for biotesting as antitumor agents.
About the Authors
V. I. Potkin
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Corresponding Member, D. Sc. (Chemistry), Professor, Head of the Department
A. V. Kletskov
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Researcher
S. K. Petkevich
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Ph. D. (Chemistry), Senior researcher
I. A. Kolesnik
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Junior researcher
F. I. Zubkov
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Ph. D. (Chemistry), Assistant Professor
E. A. Kvyatkovskaya
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
K. K. Borisova
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Assistant
A. V. Popov
A. E. Favorskii Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Ph. D. (Chemistry), Researcher
I. B. Rozentsveig
A. E. Favorskii Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
D. Sc. (Chemistry), Assistant Professor, Deputy Director
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