INFLUENCE OF EXOGENOUS LACTOFERRIN ON THE DEVELOPMENT OF AN EXPERIMENTAL MODEL OF MAMMARY GLAND CARCINOMA

A systemic administration of lactoferrin per os suppressed the development of Ehrlich’s carcinoma by 39.4 %. In this case, positive actions upon the state of antioxidant and immune systems were observed: decrease in the peroxidation of proteins and increase in the antioxidant activity; the restoration of IL-1β and TGF β1 levels with a statistically reliable increase in the blood serum TNF-α, which, as known, suppresses the growth of tumor cells and regulates a number of metabolic processes, and also the activity of immune response. At the same time, a decrease in the blood serum of the content of testosterone and estradiol is shown. The revealed effect of lactoferrin suppression of the development of tumor is apparently associated with a significant (by a factor of 5.28) increase in the blood serum of the iron concentration, which plays an important role in providing regulation systems of the vital activity of tumor cells. 

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