CHANGES OF THE MICROCIRCULATORY SKIN BED AND ORGANS ASSOCIATED WITH THE HORMONAL-BIOCHEMICAL BACKGROUND IN WISTAR RATS WHEN MODELING DIABETES MELLITUS
https://doi.org/10.29235/1561-8323-2018-62-1-101-108
Abstract
Spasm of arterioles (thickening of the smooth muscle cell layer), endothelial desquamation and neutrophilic perivascular infiltration are often observed in the microvasculature on the background of diabetes mellitus. Microangiopathies of the skin and internal organs develop in parallel and are comparable in nature with morphological changes. The level of renin significantly increases in diabetes mellitus, which indicates an early involving of mechanisms of renal pathology and development of arterial hypertension. Osteocalcin reduces in diabetes mellitus, which is associated with severe (possibly irreversible) metabolic disorders of bone tissue and osteoblast death.
About the Authors
Elena I. Kalinovskaya
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Ph. D. (Medicine), Head of the Laboratory
28, Akademicheskaya Str., 220072, Minsk
Lyudmila I. Archakova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
D. Sc. (Biology), Chief Researcher, Professor
28, Akademicheskaya Str., 220072, Minsk
Tatyana E. Kuznetsova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Ph. D. (Biology). Head of the Laboratory
28, Akademicheskaya Str., 220072, Minsk
Elena L. Ryzhkovskaya
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Senior Researcher
28, Akademicheskaya Str., 220072, Minsk
Tatyana A. Mityukova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Ph. D. (Biology), Leading researcher
28, Akademicheskaya Str., 220072, Minsk
Olga E. Poluliakh
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Researcher
28, Akademicheskaya Str., 220072, Minsk
Anastasia A. Basalai
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Junior Researcher
28, Akademicheskaya Str., 220072, Minsk,
Tatyana V. Balashevich
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Researcher
28, Akademicheskaya Str., 220072, Minsk
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