SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 1,4- AND 1,4,5-SUBSTITUTED-1H-1,2,3TRIAZOLES IN RELATION TO THE STAPHYLOCOCCUS AUREUS STRAIN
https://doi.org/10.29235/1561-8323-2018-62-3-293-297
Abstract
A number of 1,4- and 1,4,5-triazoles have been synthesized using a modified catalytic system for the Huisgen [3+2] cycloaddition reaction. The bactericidal activity of the synthesized compounds has been studied. The synthesized derivatives of 1H-1,2,3-triazoles have demonstrated higher antibacterial activities in relation to the pathogen Staphylococcus aureus strain which can be comparable with the clinically used antibiotic “Cefotaxime”.
About the Authors
A. V. Zuraev
Research Institute for Physical Chemical Problems of the Belarusian State University.
Russian Federation
Russian Federation
Zuraev Alexander Victorovich – Junior researcher.
14, Leningradskaya Str., 220030, Minsk.
A. V. Lishai
Belarusian State Medical University .
Russian Federation
Russian Federation
Lishai Anastasia Victorovna – Assistant.
83, Dzerzhinsky Ave., 220116, Minsk.
Yu. V. Grigoriev
Research Institute for Physical Chemical Problems of the Belarusian State University.
Russian Federation
Russian Federation
Grigoriev Yuri Victorovich – Ph. D. (Chemistry), Head of Laboratory.
14, Leningradskaya Str., 220030, Minsk.
O. A. Ivashkevich
Belarusian State University.
Russian Federation
Russian Federation
Ivashkevich Oleg Anatolievich – Academician, D. Sc. (Chemistry), Professor, First prorector.
4, Nezavisimosti Ave., 220030, Minsk.
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