Synthons for new 11-deoxy-3-oxa-3,7-inter-m-phenylene prostaglandin analogues
https://doi.org/10.29235/1561-8323-2019-63-3-291-297
Abstract
A synthetic scheme for obtaining cyclopentenone synthons for metabolically stable 11-deoxy-3-oxa-3,7-inter-m-phenylene prostaglandin analogues has been developed. The key step of the scheme is the Knoevenagel condensation of cyclopentane-1,3-dione with the readily available 3-(formylphenoxy)acetic acid methyl ester in the presence of Hantzsh ester.
About the Authors
F. S. Pashkovsky
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Pashkovsky Felix Sigizmundovich – Ph. D. (Chemistry), Head of the Laboratory
5/2, Kuprevich Str., 220141, Minsk, Republic of Belarus
D. I. Korneev
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Korneev Dmitry Igorevich– Junior researcher
5/2, Kuprevich Str., 220141, Minsk, Republic of Belarus
F. A. Lakhvich
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Lakhvich Fedor Adamovich – Academician, D. Sc. (Chemistry), Professor, Chief researcher
5/2, Kuprevich Str., 220141, Minsk, Republic of Belarus
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