Features of the glucose influence on the heart activity and the changes in the potentials of the stomach and the intestines at the heart insufficiency conditions
https://doi.org/10.29235/1561-8323-2019-63-6-736-746
Abstract
In acute rat experiments (thiopental sodium narcosis), it is established that introducing a 5 % glucose solution into the stomach lowers a frequency of heart rates (HR) and an amplitude of potentials of smooth muscles of the stomach and simultaneously raises doubtfully and shortly the potentials of sooth muscles (PSM) of the colon. Food additives used in the glutamate sodium, benzoate, tartrazine complex do not influence HR, but as before, reduces PSM of the stomach, and in the thick gut precise exciting or brake responses are marked. In the preliminarily developed heart insufficiency conditions, the glucose infusion into the stomach does not change HR. At the same time, the action of glucose, as well as of food additives, still results in reliable reactions of the stomach and the thick gut. Important is the present work information on the ability of glucose and food additives to modulate the heart activity estimated through the indicators of modification of electrocardiogram teeth. As appeared, the infusion of the specified irritants in the stomach of rats in control and heart insufficiency is accompanied by precise enough changes in such indicators as the RST duration, the amplitude and duration of the Т-wave,
i. e. the prognostic attributes of the opportunity of occurrence of heart аrrhythmia, fibrillations.
About the Authors
V. V. Soltanov
Institute of Physiology of the National Academy of Sciences of Belarus
Russian Federation
Russian Federation
Soltanov Vladimir Vsevolodovich – Corresponding Member, D. Sc. (Biology), Professor, Chief researcher.
28, Akademicheskaya Str., 220072, Minsk
L. M. Komarovskaya
Institute of Physiology of the National Academy of Sciences of Belarus
Russian Federation
Russian Federation
Komarovskaya Ludmila Mikhailovna – Researcher.
28, Akademicheskaya Str., 220072, Minsk
References
1. Browning K. N., Travagli R. A. Central Nervous System Control Gastrointestinal Motility and Secretion and Modulation of Gastrointestinal Functions. Comprehensive Physiology, 2014, vol. 4, no. 4, pp. 1339–1368. https://doi. org/10.1002/cphy.c130055
2. Valentino R. J., Guyenet P., Hou X. H., Herman M. Central Network Dynamics Regulating Visceral and Humoral Functions. Journal of Neuroscience, 2017, vol. 37, no. 45, pp. 10848–10854. https://doi.org/10.1523/jneurosci.1833-17.2017
3. Soltanov V. V. Role of intestinal microbiota in the mechanisms of nervous regulation of vegetative functions. News of Biomedical Sciences, 2015, vol. 11, no. 2, pp. 106–111 (in Russian).
4. Soltanov V. V. Mechanisms of self-regulation of vegetative functions in health and in disease. Minsk, 1994. 335 p. (in Russian).
5. Spallone V. Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What is Defined, What is New, and What Is Unmet. Diabetes and Metabolism Journal, 2019, vol. 43, no. 1, pp. 3–30. https:// doi.org/10.4093/dmj.2018.0259
6. Sergeev V. A., Soltanov V. V., Komarovskaya L. M. Activity of the stomach smooth muscles when acted upon by synaptically active drugs before and after forming experimental abdominal inflammation. News of Biomedical Sciences, 2014, vol. 10, no. 4, pp. 157–164. (in Russian).
7. Azev O. A., Burko V. E., Soltanov V. V. Sofware product “Inputwin”: for recording and analysis of electrophysiological data. News of Biomedical Sciences, 2010, vol. 2, no. 4, pp. 152–155 (in Russian).
8. Martsinkevich E. V. Viscerocardial effects initiated by glucose introduced into the duodenum. News of Biomedical Sciences, 2012, vol. 6, no. 3, pp. 27–31 (in Russian).
9. Itina L. V. Receptor function of the small gut. Minsk, 1972. 205 p. (in Russian).
10. Roberts B. L., Zhu M., Zhao H., Dillon C., Appleyard S. M. High glucose increases action potential firing of catecholamine neurons in the nucleus of the solitary tract by increasing spotaneous glutamate inputs. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2017, vol. 313, no. 3, pp. R229–R239. https://doi. org/10.1152/ajpregu.00413.2016
11. Alvarsson A., Stanley S. A. Remote control of glucose-sensing neurons to analyze glucose metabolism. American Journal of Physiology Endocrinology and Metabolism, 2018, vol. 315, no. 3, pp. E327–E339. https://doi.org/10.1152/ ajpendo.00469.2017
12. Boychuk C. R., Smith K. Cs., Peterson L. E., Boychuk J. A., Butter C. R., Derera I. D., McCarthy J. J., Smith B. N. A hindbrain inthibitory microcircuit mediates vagally-coordinated glucose regutation. Scientific Reports, 2019, vol. 9, no. 1, pp. 2722. https://doi.org/10.1038/s41598-019-39490-x
13. Rahm A.-K., Lugenbiel P., Schweizer P. A., Katus H. A., Thomas D. Role of ion channels in heart failure and channelopathies. Biophysical Reviews, 2018, vol. 10, no. 4, pp. 1097–1106. https://doi.org/10.1007/s12551-018-0442-3
14. Ramirez J., Orini M., Minchole A., Monasterio V., Cygankiewicz I., Bayes de Luna A., Martinez J. P., Pueyo E., Laguna P. T-wave Morphology Restitution Predicts Sudden Cardiac Death in Patients with Chronic Heart Failure. Journal of the American Heart Association, 2017, vol. 6, no. 5, art. e005310. https://doi.org/10.1161/jaha.116.005310
15. Aune D., Feng T., Schlesinger S., Janszky I., Norat T., Riboli E. Diabetes mellitus, blood glucose and the risk of atrial fibrillation: A systematic review and meta-analysis of cohort studies. Journal of Diabetes and its Complicatios, 2018, vol. 32, no. 5, pp. 501–511. https://doi.org/10.1016/j.jdiacomp.2018.02.004
Review
Views: 1910
Email this article 